Source:http://linkedlifedata.com/resource/pubmed/id/15856211
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2005-6-22
|
| pubmed:abstractText |
alphaB-crystallin (alpha-BC), a member of the small heat-shock proteins (sHSP), is constitutively expressed in the vertebrate lens and in non-ocular tissues including the central nervous system (CNS). In this study we investigated the expression of alpha-BC in the rat brain after middle cerebral artery occlusion (MCAO). alpha-BC transcript and protein were transiently expressed 4 h after MCAO/reperfusion in the pyramidal neurons in the peri-infarct region of the ischemic hemisphere. Beginning 2 days after MCAO, significant alpha-BC induction appeared in reactive astrocytes in the penumbra, and this induction was sustained for several days. In addition, levels of MAPKAPK-2, one of the alpha-BC upstream kinases, and its phosphorylated form were upregulated gradually and peaked 4 days after ischemia/reperfusion injury. The immunohistochemical study indicated that alpha-BC was co-localized with MAPKAPK-2 and p-MAPKAPK-2. Furthermore, p38beta MAPK, an upstream kinase of MAPKAPK-2, which has been known to be involved in compensatory responses to stress, was also co-localized with alpha-BC in the penumbra. Our results suggest that the p38beta-dependent alpha-BC induction in neurons and astrocytes in the penumbra may play an important role in the postischemic brain.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/MAP-kinase-activated kinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-Crystallin B Chain,
http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0014-4819
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
163
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
421-9
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:15856211-Animals,
pubmed-meshheading:15856211-Astrocytes,
pubmed-meshheading:15856211-Cerebral Cortex,
pubmed-meshheading:15856211-Cerebral Infarction,
pubmed-meshheading:15856211-Disease Models, Animal,
pubmed-meshheading:15856211-Infarction, Middle Cerebral Artery,
pubmed-meshheading:15856211-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:15856211-Ischemic Attack, Transient,
pubmed-meshheading:15856211-Male,
pubmed-meshheading:15856211-Nerve Degeneration,
pubmed-meshheading:15856211-Protein-Serine-Threonine Kinases,
pubmed-meshheading:15856211-Pyramidal Cells,
pubmed-meshheading:15856211-Rats,
pubmed-meshheading:15856211-Rats, Sprague-Dawley,
pubmed-meshheading:15856211-Reperfusion Injury,
pubmed-meshheading:15856211-Stress, Physiological,
pubmed-meshheading:15856211-Up-Regulation,
pubmed-meshheading:15856211-alpha-Crystallin B Chain,
pubmed-meshheading:15856211-p38 Mitogen-Activated Protein Kinases
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
Co-induction of alphaB-crystallin and MAPKAPK-2 in astrocytes in the penumbra after transient focal cerebral ischemia.
|
| pubmed:affiliation |
Department of Anatomy, Inha University School of Medicine, Jung-Gu Shinheung-Dong 3rd. St. 7-241, 400-712 Inchon, Korea.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|