Linked Life Data

15825320

Source:http://linkedlifedata.com/resource/pubmed/id/15825320

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2005-4-13
pubmed:abstractText
Prior investigators have reported a broad gram-negative spectrum and a marked anti-Pseudomonas activity in vitro with BL-P1654, 6-[R-alpha-(guanylureido)phenylacetamido]-penicillanic acid. An in vitro comparison of BL-P1654 to carbenicillin was performed against 84 strains of Pseudomonas and 39 strains of Enterobacteriaceae. Mean minimal inhibitory concentrations in Mueller-Hinton broth of BL-P1654 and carbenicillin were 12.5 and 100 mug/ml, respectively. Bactericidal studies with representative strains of Pseudomonas showed a consistent lack of bactericidal activity with BL-P1654. Mean bactericidal concentrations of BL-P1654 and carbenicillin were >/=200 and 100 mug/ml, respectively. The lack of bactericidal activity of BL-P1654 was further substantiated with the "killing curve" technique. Based on these data, BL-P1654 can not be considered a substitute for carbenicillin as the penicillin analogue of choice for Pseudomonas infections.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0066-4804
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
643-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1974
pubmed:articleTitle
Comparative in vitro evaluation of BL-P1654 and carbenicillin against Pseudomonas.
pubmed:publicationType
Journal Article, Comparative Study