Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2005-4-4
pubmed:abstractText
Microcystins, a family of cyclic heptapeptides produced by the cyanobacteria, Microcystis aeruginosa, have documented hepatotoxic and tumor promoting activities. The purpose of this study was to evaluate the toxicity of inhaled microcystin LR (microcystin). Male BALB/c mice were exposed by nose-only inhalation to 260-265 microg microcystin/m(3) for 7 days. The low-, mid- and high-dose groups were exposed for 0.5, 1, and 2h, respectively. Control animals were sham exposed to aerosolized vehicle. Treatment-related microscopic lesions were observed only in the nasal cavity of the mid- and high-dose groups. These lesions consisted of minimal to moderate multifocal degeneration and necrosis of the respiratory epithelium, with variable neutrophilic inflammation and minimal to marked degeneration, necrosis, and atrophy of the olfactory epithelium. The no-adverse-effect dose for the nasal lesions was approximately 3 microg/kg body weight, or 20 ng/cm(2) of nasal epithelium. In serum, only two protein peaks, occurring at m/zs of 11,688 and 11,829 Da, exhibited decreases in intensity that were microcystin dose-dependent. While these proteins have not been positively identified, they may be useful in the future as biomarkers of microcystin exposure in humans.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/15804518-10215106, http://linkedlifedata.com/resource/pubmed/commentcorrection/15804518-10379944, http://linkedlifedata.com/resource/pubmed/commentcorrection/15804518-10771585, http://linkedlifedata.com/resource/pubmed/commentcorrection/15804518-10978744, http://linkedlifedata.com/resource/pubmed/commentcorrection/15804518-11384614, http://linkedlifedata.com/resource/pubmed/commentcorrection/15804518-11485863, http://linkedlifedata.com/resource/pubmed/commentcorrection/15804518-12076656, http://linkedlifedata.com/resource/pubmed/commentcorrection/15804518-12505349, http://linkedlifedata.com/resource/pubmed/commentcorrection/15804518-1618889, http://linkedlifedata.com/resource/pubmed/commentcorrection/15804518-1644701, http://linkedlifedata.com/resource/pubmed/commentcorrection/15804518-2133099, http://linkedlifedata.com/resource/pubmed/commentcorrection/15804518-2191690, http://linkedlifedata.com/resource/pubmed/commentcorrection/15804518-2497311, http://linkedlifedata.com/resource/pubmed/commentcorrection/15804518-3140425, http://linkedlifedata.com/resource/pubmed/commentcorrection/15804518-3857624, http://linkedlifedata.com/resource/pubmed/commentcorrection/15804518-3892021, http://linkedlifedata.com/resource/pubmed/commentcorrection/15804518-6342208, http://linkedlifedata.com/resource/pubmed/commentcorrection/15804518-6424323, http://linkedlifedata.com/resource/pubmed/commentcorrection/15804518-8262133, http://linkedlifedata.com/resource/pubmed/commentcorrection/15804518-8408000, http://linkedlifedata.com/resource/pubmed/commentcorrection/15804518-8580413, http://linkedlifedata.com/resource/pubmed/commentcorrection/15804518-8672541, http://linkedlifedata.com/resource/pubmed/commentcorrection/15804518-9403968, http://linkedlifedata.com/resource/pubmed/commentcorrection/15804518-9438419, http://linkedlifedata.com/resource/pubmed/commentcorrection/15804518-9516222, http://linkedlifedata.com/resource/pubmed/commentcorrection/15804518-9690788, http://linkedlifedata.com/resource/pubmed/commentcorrection/15804518-9733865
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0041-0101
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
691-8
pubmed:dateRevised
2011-8-1
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
The toxicity of microcystin LR in mice following 7 days of inhalation exposure.
pubmed:affiliation
Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr. SE, Albuquerque, NM 87108, USA. jbenson@lrri.org
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, N.I.H., Extramural