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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2005-3-30
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pubmed:abstractText |
Mcl-1 is one Bcl-2 family member that plays a pivotal role in animal development. The extremely labile nature of the Mcl-1 protein itself and the fact that the Mcl-1 level is a critical determinant in various cell survival pathways suggest that cellular processes that regulate Mcl-1 stability are as important as those that regulate Mcl-1 synthesis. Although transcriptional stimulation of Mcl-1 synthesis in response to various stimuli has been well documented, regulation of Mcl-1 stability has been hardly explored. In this study, we identified that the translationally controlled tumor protein (TCTP) was one cellular factor that interacted with Mcl-1 and modulated Mcl-1 stability. While overexpression of TCTP augmented the protein stability of Mcl-1, knockdown expression of TCTP by RNA interference destabilized Mcl-1. Furthermore, TCTP stabilized Mcl-1 through interfering with Mcl-1's degradation by the ubiquitin-dependent proteasome degradation pathway, and the TCTP binding-defective mutant of Mcl-1 (K257V) was much more susceptible to degradation and manifested a compromised antiapoptotic activity. Taken together, these results suggest that TCTP modulates Mcl-1's antiapoptotic activity by modulating its protein stability. The possible mechanism(s) involved in TCTP's modulation process is discussed.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-10454566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-10640272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-10733576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-10763823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-10961875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-11163351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-11175262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-11457886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-11473261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-11598139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-11698499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-11910072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-11960321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-12149273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-12167714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-12399545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-12612065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-12783855,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-14623968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-14633975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-14668867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-2011514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-2479380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-6577280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-7542803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-7682708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-7896880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-7987827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-8345191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-8548771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-8600156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-8605321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-8692274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-9002967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-9356461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-9671497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-9742125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15798198-9746790
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Lysine,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteasome Endopeptidase Complex,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitin,
http://linkedlifedata.com/resource/pubmed/chemical/myeloid cell leukemia sequence 1...,
http://linkedlifedata.com/resource/pubmed/chemical/translationally controlled tumor...
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3117-26
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15798198-Amino Acid Sequence,
pubmed-meshheading:15798198-Amino Acid Substitution,
pubmed-meshheading:15798198-Animals,
pubmed-meshheading:15798198-Apoptosis,
pubmed-meshheading:15798198-Binding Sites,
pubmed-meshheading:15798198-Cell Line,
pubmed-meshheading:15798198-Down-Regulation,
pubmed-meshheading:15798198-Lysine,
pubmed-meshheading:15798198-Mice,
pubmed-meshheading:15798198-Molecular Sequence Data,
pubmed-meshheading:15798198-Mutation,
pubmed-meshheading:15798198-Neoplasm Proteins,
pubmed-meshheading:15798198-Proteasome Endopeptidase Complex,
pubmed-meshheading:15798198-Protein Interaction Mapping,
pubmed-meshheading:15798198-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:15798198-RNA, Small Interfering,
pubmed-meshheading:15798198-RNA Interference,
pubmed-meshheading:15798198-Transcriptional Activation,
pubmed-meshheading:15798198-Tumor Markers, Biological,
pubmed-meshheading:15798198-Two-Hybrid System Techniques,
pubmed-meshheading:15798198-Ubiquitin
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pubmed:year |
2005
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pubmed:articleTitle |
Stabilization and enhancement of the antiapoptotic activity of mcl-1 by TCTP.
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pubmed:affiliation |
Institute of Molecular Biology, Academia Sinica, 128 Yen-Jiou Yuan Rd., Section 2, Nankang, Taipei 11529, Taiwan.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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