Source:http://linkedlifedata.com/resource/pubmed/id/15793610
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2005-3-28
|
| pubmed:abstractText |
Endothelial dysfunction plays an important role in the pathogenesis of cardiac syndrome X, and intracoronary low-dose acetylcholine infusion is a widely used diagnostic modality for studying the coronary artery endothelial function. The authors herein report 2 cases of cardiac syndrome X with coronary artery endothelial dysfunction and microvessel spasm. The findings of non-invasive testing were positive for ischemia. Coronary angiograms appeared entirely normal in both cases. However, the intracoronary infusion of low-dose (1.5-15 microg/minute) acetylcholine demonstrated an impairment of the coronary blood flow response and consequently provoked an ST-segment elevation in an electrocardiogram. The coronary angiograms showed no spasm in the epicardial arteries. These patients are thus suggested to have cardiac syndrome X with microvessel spasms associated with coronary artery endothelial dysfunction.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0003-3197
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
56
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
211-6
|
| pubmed:meshHeading |
pubmed-meshheading:15793610-Acetylcholine,
pubmed-meshheading:15793610-Blood Flow Velocity,
pubmed-meshheading:15793610-Cholinergic Agents,
pubmed-meshheading:15793610-Coronary Angiography,
pubmed-meshheading:15793610-Coronary Circulation,
pubmed-meshheading:15793610-Coronary Disease,
pubmed-meshheading:15793610-Coronary Vasospasm,
pubmed-meshheading:15793610-Diagnosis, Differential,
pubmed-meshheading:15793610-Dose-Response Relationship, Drug,
pubmed-meshheading:15793610-Electrocardiography,
pubmed-meshheading:15793610-Endothelium, Vascular,
pubmed-meshheading:15793610-Female,
pubmed-meshheading:15793610-Humans,
pubmed-meshheading:15793610-Injections, Intra-Arterial,
pubmed-meshheading:15793610-Magnetic Resonance Angiography,
pubmed-meshheading:15793610-Male,
pubmed-meshheading:15793610-Microcirculation,
pubmed-meshheading:15793610-Microvascular Angina,
pubmed-meshheading:15793610-Middle Aged
|
| pubmed:articleTitle |
Provocation of microvessel spasm by low-dose acetylcholine in patients with suspected coronary artery disease--two case reports.
|
| pubmed:affiliation |
The First Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
|
| pubmed:publicationType |
Journal Article,
Case Reports
|