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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2005-3-22
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pubmed:abstractText |
Granulocyte/macrophage colony-stimulating factor (GM-CSF) promotes the survival, proliferation, and differentiation of myeloid lineage cells and regulates chemotaxis and adhesion. However, mice in which the genes encoding GM-CSF (Gmcsf) or the beta common subunit of the GM-CSF receptor (betac) are inactivated display normal steady-state hematopoiesis. Here, we show that host GM-CSF signaling strongly modulates the ability of donor hematopoietic cells to radioprotect lethally irradiated mice. Although bone marrow mononuclear cells efficiently rescue Gmcsf mutant recipients, fetal liver cells and Sca1(+) lin(-/dim) marrow cells are markedly impaired. This defect is partially attributable to accessory cells that are more prevalent in bone marrow. In contrast, Gmcsf-deficient hematopoietic stem cells demonstrate normal proliferative potentials. Short-term survival is also impaired in irradiated betac mutant recipients transplanted with fetal liver or bone marrow. These data demonstrate a nonredundant function of GM-CSF in radioprotection by donor hematopoietic cells that may prove relevant in clinical transplantation.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15781578-10084250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15781578-10381491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15781578-10652277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15781578-10678181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15781578-10754327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15781578-11172139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15781578-11342418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15781578-11442488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15781578-12070305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15781578-12732663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15781578-14564341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15781578-14701873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15781578-15310902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15781578-1903847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15781578-2194592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15781578-2965305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15781578-7568173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15781578-7662961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15781578-7697542,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15781578-8171324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15781578-8202532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15781578-8536785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15781578-8978278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15781578-9057626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15781578-9131003
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
201
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
853-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15781578-Animals,
pubmed-meshheading:15781578-Bone Marrow Transplantation,
pubmed-meshheading:15781578-Cell Proliferation,
pubmed-meshheading:15781578-Cell Separation,
pubmed-meshheading:15781578-Female,
pubmed-meshheading:15781578-Fetus,
pubmed-meshheading:15781578-Gamma Rays,
pubmed-meshheading:15781578-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:15781578-Liver,
pubmed-meshheading:15781578-Mice,
pubmed-meshheading:15781578-Myeloid Progenitor Cells,
pubmed-meshheading:15781578-Myelopoiesis,
pubmed-meshheading:15781578-Nerve Tissue Proteins,
pubmed-meshheading:15781578-Nuclear Proteins,
pubmed-meshheading:15781578-Receptors, Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:15781578-Signal Transduction,
pubmed-meshheading:15781578-Whole-Body Irradiation
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pubmed:year |
2005
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pubmed:articleTitle |
Granulocyte/macrophage colony-stimulating factor and accessory cells modulate radioprotection by purified hematopoietic cells.
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pubmed:affiliation |
Department of Pediatrics, University of California, San Francisco, CA 94143, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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