| pubmed-article:15769121 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15769121 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:15769121 | lifeskim:mentions | umls-concept:C0757672 | lld:lifeskim |
| pubmed-article:15769121 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:15769121 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:15769121 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:15769121 | lifeskim:mentions | umls-concept:C0071649 | lld:lifeskim |
| pubmed-article:15769121 | lifeskim:mentions | umls-concept:C2347919 | lld:lifeskim |
| pubmed-article:15769121 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:15769121 | pubmed:dateCreated | 2005-3-16 | lld:pubmed |
| pubmed-article:15769121 | pubmed:abstractText | A moderate consumption of red wine may reduce the risk of cardiovascular diseases via wine-derived phenolic compounds. A variety of biological mechanisms have been proposed for wine-derived phenolic compounds including nitric oxide-mediated vasorelaxation. This study examined whether the vasodilating effect of wine-derived phenolic compounds was associated with the inhibition of phosphodiesterases (PDEs) and, in particular, PDE5. For this purpose, human recombinant PDE5A1 isoform was prepared by expression of the full-length cDNA of PDE5A1 into COS-7 cells. Red wine and the extracts from grape skin inhibited PDE5A1 activity, whereas the seed extracts had a negligible effect. The mixture of anthocyanins inhibited the enzyme activity (IC50 = 11.6 microM), with malvidin-3-O-beta-glucoside (IC50 = 35.4 microM) and malvidin (IC50 = 24.9 microM) the most potent among the monoglucosides and aglycons, respectively. trans-Resveratrol and trans-piceid exhibited negligible effects, whereas hydroxycinnamates were completely inactive. These results indicate that polyphenols-induced vasorelaxation may also be sustained by smooth muscle PDE inhibition by anthocyanins present in red wines and grapes. | lld:pubmed |
| pubmed-article:15769121 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15769121 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15769121 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15769121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15769121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15769121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15769121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15769121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15769121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15769121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15769121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15769121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15769121 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15769121 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:15769121 | pubmed:issn | 0021-8561 | lld:pubmed |
| pubmed-article:15769121 | pubmed:author | pubmed-author:Dell'AgliMari... | lld:pubmed |
| pubmed-article:15769121 | pubmed:author | pubmed-author:BosisioEnrica... | lld:pubmed |
| pubmed-article:15769121 | pubmed:author | pubmed-author:VrhovsekUrska... | lld:pubmed |
| pubmed-article:15769121 | pubmed:author | pubmed-author:MattiviFulvio... | lld:pubmed |
| pubmed-article:15769121 | pubmed:author | pubmed-author:GalliGermana... | lld:pubmed |
| pubmed-article:15769121 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15769121 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:15769121 | pubmed:volume | 53 | lld:pubmed |
| pubmed-article:15769121 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15769121 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15769121 | pubmed:pagination | 1960-5 | lld:pubmed |
| pubmed-article:15769121 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:15769121 | pubmed:meshHeading | pubmed-meshheading:15769121... | lld:pubmed |
| pubmed-article:15769121 | pubmed:meshHeading | pubmed-meshheading:15769121... | lld:pubmed |
| pubmed-article:15769121 | pubmed:meshHeading | pubmed-meshheading:15769121... | lld:pubmed |
| pubmed-article:15769121 | pubmed:meshHeading | pubmed-meshheading:15769121... | lld:pubmed |
| pubmed-article:15769121 | pubmed:meshHeading | pubmed-meshheading:15769121... | lld:pubmed |
| pubmed-article:15769121 | pubmed:meshHeading | pubmed-meshheading:15769121... | lld:pubmed |
| pubmed-article:15769121 | pubmed:meshHeading | pubmed-meshheading:15769121... | lld:pubmed |
| pubmed-article:15769121 | pubmed:meshHeading | pubmed-meshheading:15769121... | lld:pubmed |
| pubmed-article:15769121 | pubmed:meshHeading | pubmed-meshheading:15769121... | lld:pubmed |
| pubmed-article:15769121 | pubmed:meshHeading | pubmed-meshheading:15769121... | lld:pubmed |
| pubmed-article:15769121 | pubmed:meshHeading | pubmed-meshheading:15769121... | lld:pubmed |
| pubmed-article:15769121 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15769121 | pubmed:articleTitle | In vitro inhibition of human cGMP-specific phosphodiesterase-5 by polyphenols from red grapes. | lld:pubmed |
| pubmed-article:15769121 | pubmed:affiliation | Department of Pharmacological Sciences, Faculty of Pharmacy, University of Milan, via Balzaretti 9, 20133 Milan, Italy. mario.dellagli@unimi.it | lld:pubmed |
| pubmed-article:15769121 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15769121 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15769121 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15769121 | lld:pubmed |
