Source:http://linkedlifedata.com/resource/pubmed/id/15738240
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2005-3-1
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| pubmed:abstractText |
Circulating levels of vitamin A (retinol) and lactoferrin (Lf) are low in calves at birth. Bovine colostrum contains relatively high amounts of vitamin A and Lf, and both substances are intestinally absorbed by neonatal calves. There is evidence that these compounds interact with insulin-like growth factor binding proteins and thus influence the status and effects of insulin-like growth factor. The hypothesis was therefore tested that vitamin A and Lf influence epithelial growth, development, and absorptive capacity of the small and large intestine and modulate intestinal immune tissues (Peyer's patches; PP). Four groups of calves (n = 7 per group) were fed a milk-based formula with or without vitamin A and (or) Lf. Group F received formula (F) only; group F(A) was fed F supplemented with vitamin A; group F(L) was fed F supplemented with Lf, and group F(AL) received F plus vitamin A plus Lf. An additional group of calves (group C; n = 7) served as positive control and was fed colostrum (C) from pooled milk obtained on d 1, 2, and 3 of lactation. Amounts of nutritive components in formula and colostrum were similar. Blood samples were taken to measure vitamin A and Lf, and plasma xylose (added on d 4 to feeds) was measured postprandially for 8 h as a marker of intestinal absorptive capacity. Plasma vitamin A was low at birth and further decreased in groups F and F(L), but increased in groups F(A), F(AL), and C. Plasma Lf was low at birth and transiently increased up to 4 h after the first meal in group C. Xylose absorption was higher in group C than in other groups. Incorporation of 5-bromo-2'-deoxyuridine into DNA (as a measure of cell proliferation rate) was enhanced in intestinal crypts in groups F and F(L) at all intestinal sites. Ileum villus heights of groups F and F(L) were smaller than of groups F(A) and F(AL). Villus height to crypt depth ratios were smaller in F-fed groups (especially in groups F and F(L)) than in C-fed calves in the duodenum and jejunum. Incorporation of 5-bromo-2'-deoxyuridine into colon crypt cells of group F was greater than in groups F(L) and F(A). Sizes of follicles of PP in the ileum were greater in group F(A) than in group F. In the ileum, vitamin A and Lf tended to interact with PP size. In conclusion, feed supplementation of vitamin A and Lf influenced growth of the ileum and colon. Interactions were observed between vitamin A and Lf on epithelial cell maturation, villus growth, and size of follicles in PP of neonatal calves.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
0022-0302
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
88
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1050-61
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:15738240-Analysis of Variance,
pubmed-meshheading:15738240-Animal Nutritional Physiological Phenomena,
pubmed-meshheading:15738240-Animals,
pubmed-meshheading:15738240-Animals, Newborn,
pubmed-meshheading:15738240-Cattle,
pubmed-meshheading:15738240-Cell Division,
pubmed-meshheading:15738240-Colon,
pubmed-meshheading:15738240-Colostrum,
pubmed-meshheading:15738240-Epithelial Cells,
pubmed-meshheading:15738240-Ileum,
pubmed-meshheading:15738240-Intestinal Absorption,
pubmed-meshheading:15738240-Intestinal Mucosa,
pubmed-meshheading:15738240-Intestines,
pubmed-meshheading:15738240-Lactoferrin,
pubmed-meshheading:15738240-Lymphoid Tissue,
pubmed-meshheading:15738240-Male,
pubmed-meshheading:15738240-Peyer's Patches,
pubmed-meshheading:15738240-Random Allocation,
pubmed-meshheading:15738240-Somatomedins,
pubmed-meshheading:15738240-Vitamin A
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| pubmed:year |
2005
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| pubmed:articleTitle |
Effects of feeding vitamin A and lactoferrin on epithelium of lymphoid tissues of intestine of neonatal calves.
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| pubmed:affiliation |
Division of Nutrition and Physiology, Institute of Animal Genetics, Nutrition and Housing, Vetsuisse Faculty, University of Berne, CH-3012 Berne, Switzerland.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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