| pubmed-article:15736421 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15736421 | lifeskim:mentions | umls-concept:C0006142 | lld:lifeskim |
| pubmed-article:15736421 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:15736421 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:15736421 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:15736421 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:15736421 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:15736421 | pubmed:dateCreated | 2005-3-1 | lld:pubmed |
| pubmed-article:15736421 | pubmed:abstractText | Twist, a transcription factor of the basic helix-loop-helix class, has been suggested to have oncogenic properties. We reported Twist expression was regulated by Wnt/beta-catenin signaling and that both Wnt-1 and Twist could contribute to mammary tumorigenesis. The aim of this study was to demonstrate the expression of Twist, Wnt-1 and Wnt-2 in human breast cancer tissue. We examined the expression in patients with breast cancer by RT-PCR and immunohistochemistry. RT-PCR of twenty-three pairs of cancer and normal breast tissue revealed that Twist was up-regulated in 69.6% (16/23) of the cancer lesions and 21.7% (5/23) of the normal breast tissues. Wnt-2 was up-regulated in all of the cancer lesions and 13.0% (3/23) of the normal breast tissues, whereas Wnt-1 was expressed in both the cancer and normal breast tissues of the five cases examined. Immunohistochemical analyses revealed that Twist was positively expressed in 52.2% (12/23) of the cancer lesions and 34.8% (8/23) of the normal breast tissues. Twist and Wnt-2 are highly expressed in breast cancer tissue, suggesting that both molecules could play important roles in mammary carcinogenesis. | lld:pubmed |
| pubmed-article:15736421 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15736421 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15736421 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15736421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15736421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15736421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15736421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15736421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15736421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15736421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15736421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15736421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15736421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15736421 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15736421 | pubmed:issn | 0250-7005 | lld:pubmed |
| pubmed-article:15736421 | pubmed:author | pubmed-author:ImamuraHirosh... | lld:pubmed |
| pubmed-article:15736421 | pubmed:author | pubmed-author:OgawaKenjiK | lld:pubmed |
| pubmed-article:15736421 | pubmed:author | pubmed-author:WatanabeOsamu... | lld:pubmed |
| pubmed-article:15736421 | pubmed:author | pubmed-author:HiranoAkiraA | lld:pubmed |
| pubmed-article:15736421 | pubmed:author | pubmed-author:AibaMotohikoM | lld:pubmed |
| pubmed-article:15736421 | pubmed:author | pubmed-author:OkabeToshihir... | lld:pubmed |
| pubmed-article:15736421 | pubmed:author | pubmed-author:YoshimatsuKaz... | lld:pubmed |
| pubmed-article:15736421 | pubmed:author | pubmed-author:KinoshitaJunJ | lld:pubmed |
| pubmed-article:15736421 | pubmed:author | pubmed-author:ShimizuTadaoT | lld:pubmed |
| pubmed-article:15736421 | pubmed:author | pubmed-author:KonnoSoichiS | lld:pubmed |
| pubmed-article:15736421 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15736421 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:15736421 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15736421 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15736421 | pubmed:pagination | 3851-6 | lld:pubmed |
| pubmed-article:15736421 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
| pubmed-article:15736421 | pubmed:meshHeading | pubmed-meshheading:15736421... | lld:pubmed |
| pubmed-article:15736421 | pubmed:meshHeading | pubmed-meshheading:15736421... | lld:pubmed |
| pubmed-article:15736421 | pubmed:meshHeading | pubmed-meshheading:15736421... | lld:pubmed |
| pubmed-article:15736421 | pubmed:meshHeading | pubmed-meshheading:15736421... | lld:pubmed |
| pubmed-article:15736421 | pubmed:meshHeading | pubmed-meshheading:15736421... | lld:pubmed |
| pubmed-article:15736421 | pubmed:meshHeading | pubmed-meshheading:15736421... | lld:pubmed |
| pubmed-article:15736421 | pubmed:meshHeading | pubmed-meshheading:15736421... | lld:pubmed |
| pubmed-article:15736421 | pubmed:meshHeading | pubmed-meshheading:15736421... | lld:pubmed |
| pubmed-article:15736421 | pubmed:meshHeading | pubmed-meshheading:15736421... | lld:pubmed |
| pubmed-article:15736421 | pubmed:meshHeading | pubmed-meshheading:15736421... | lld:pubmed |
| pubmed-article:15736421 | pubmed:meshHeading | pubmed-meshheading:15736421... | lld:pubmed |
| pubmed-article:15736421 | pubmed:meshHeading | pubmed-meshheading:15736421... | lld:pubmed |
| pubmed-article:15736421 | pubmed:meshHeading | pubmed-meshheading:15736421... | lld:pubmed |
| pubmed-article:15736421 | pubmed:articleTitle | Expression of twist and wnt in human breast cancer. | lld:pubmed |
| pubmed-article:15736421 | pubmed:affiliation | Department of Surgery, Tokyo Women's Medical University, Daini Hospital, Tokyo, Japan. | lld:pubmed |
| pubmed-article:15736421 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:114487 | entrezgene:pubmed | pubmed-article:15736421 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15736421 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15736421 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15736421 | lld:pubmed |
