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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2005-3-14
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pubmed:abstractText |
Bone morphogenetic proteins (BMPs) regulate a wide range of cellular functions that contribute to embryonic development from mesoderm formation to organogenesis. BMP type II receptor (BMPR-II) transduces BMP signals by forming heteromeric complexes with and phosphorylating BMP type I receptors. Heterozygous germline mutations of BMPR-II gene have been identified in patients with familial and sporadic primary pulmonary hypertension, indicating that BMPR-II may contribute to the maintenance of normal pulmonary vascular structure and function. Since embryos homozygous for a null BMPR-II allele died during gastrulation, precluding further studies of BMPR-II function in organ formation and in adult tissues, we generated mice carrying a conditional mutant BMPR-II allele in which exons 4 and 5 were flanked by loxP sequences. We anticipate that studies of mice carrying a floxed BMPR-II allele and a Cre transgene (under the control of a tissue-specific promoter) will enable characterization of the role of BMPR-II in specific cell types during development and in the pathogenesis of cardiovascular diseases.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1526-954X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
133-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15736264-Alleles,
pubmed-meshheading:15736264-Animals,
pubmed-meshheading:15736264-Bone Morphogenetic Protein Receptors, Type II,
pubmed-meshheading:15736264-Chimera,
pubmed-meshheading:15736264-Electroporation,
pubmed-meshheading:15736264-Embryonic Development,
pubmed-meshheading:15736264-Exons,
pubmed-meshheading:15736264-Female,
pubmed-meshheading:15736264-Gene Expression Regulation, Developmental,
pubmed-meshheading:15736264-Genetic Engineering,
pubmed-meshheading:15736264-Genetic Vectors,
pubmed-meshheading:15736264-Genotype,
pubmed-meshheading:15736264-Integrases,
pubmed-meshheading:15736264-Male,
pubmed-meshheading:15736264-Mice,
pubmed-meshheading:15736264-Mice, Inbred C57BL,
pubmed-meshheading:15736264-Mice, Transgenic,
pubmed-meshheading:15736264-Protein-Serine-Threonine Kinases,
pubmed-meshheading:15736264-Receptors, Cell Surface,
pubmed-meshheading:15736264-Transgenes
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pubmed:year |
2005
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pubmed:articleTitle |
Generation of a floxed allele of the mouse BMP type II receptor gene.
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pubmed:affiliation |
Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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