Source:http://linkedlifedata.com/resource/pubmed/id/15708438
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2005-2-14
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| pubmed:abstractText |
Increased anxiety may occur in up to 70% of AD patients during the course of their illness. Here we show that human apoE isoforms, which differ in AD risk, have differential effects on measures of anxiety in adult Apoe-/- male mice expressing human apoE3 or apoE4 in their brains and male probable AD (PRAD) patients. Compared with wild-type mice, Apoe-/- mice without human apoE or with apoE4, but not apoE3, showed increased measures of anxiety. These behavioral alterations were associated with reduced microtubule-associated protein 2-positive neuronal dendrites in the central nucleus of the amygdala. Consistent with the mouse data, male and female PRAD patients with epsilon4/epsilon4 showed higher anxiety scores than those with epsilon3/epsilon3. We conclude that human apoE isoforms have differential effects on measures of anxiety.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0197-4580
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
26
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
637-43
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:15708438-Aged,
pubmed-meshheading:15708438-Aged, 80 and over,
pubmed-meshheading:15708438-Alzheimer Disease,
pubmed-meshheading:15708438-Analysis of Variance,
pubmed-meshheading:15708438-Animals,
pubmed-meshheading:15708438-Anxiety,
pubmed-meshheading:15708438-Apolipoproteins E,
pubmed-meshheading:15708438-Behavior, Animal,
pubmed-meshheading:15708438-Female,
pubmed-meshheading:15708438-Glucocorticoids,
pubmed-meshheading:15708438-Humans,
pubmed-meshheading:15708438-Hydrocortisone,
pubmed-meshheading:15708438-Immunohistochemistry,
pubmed-meshheading:15708438-Male,
pubmed-meshheading:15708438-Maze Learning,
pubmed-meshheading:15708438-Mice,
pubmed-meshheading:15708438-Mice, Inbred C57BL,
pubmed-meshheading:15708438-Mice, Knockout,
pubmed-meshheading:15708438-Middle Aged,
pubmed-meshheading:15708438-Protein Isoforms,
pubmed-meshheading:15708438-Reflex, Acoustic,
pubmed-meshheading:15708438-Sex Factors,
pubmed-meshheading:15708438-Sleep Apnea, Central
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
apoE isoforms and measures of anxiety in probable AD patients and Apoe-/- mice.
|
| pubmed:affiliation |
Department of Behavioral Neuroscience, L470, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|