| pubmed-article:15702085 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15702085 | lifeskim:mentions | umls-concept:C0014264 | lld:lifeskim |
| pubmed-article:15702085 | lifeskim:mentions | umls-concept:C0125606 | lld:lifeskim |
| pubmed-article:15702085 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:15702085 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:15702085 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:15702085 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:15702085 | lifeskim:mentions | umls-concept:C0599946 | lld:lifeskim |
| pubmed-article:15702085 | lifeskim:mentions | umls-concept:C0205227 | lld:lifeskim |
| pubmed-article:15702085 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15702085 | pubmed:dateCreated | 2005-2-9 | lld:pubmed |
| pubmed-article:15702085 | pubmed:abstractText | Leukemia inhibitory factor (LIF) is induced in inflammation and likely plays a regulatory role. Using LIF-deficient mice (LIF-/-), we report here that endogenous LIF has a protective role in endotoxic shock and host defence. LIF-/- mice have heightened sensitivity to LPS in a LPS/D-galactosamine (D-Gal) sensitization model compared to wild-type mice (LIF+/+), enhanced thrombocytopenia and leukopenia, with increased hepatic necrosis, neutrophil sequestration in the lung and accelerated mortality. These findings correlated with 10-fold higher tumour necrosis factor-alpha (TNFalpha) and interleukin-6 (IL-6) serum levels and reduced IL-10 production in LIF-/- mice in response to LPS. Therefore, endogenous LIF attenuates the endotoxic shock response, enhances the expression of basal acute phase proteins and IL-10 production, which downregulates TNFalpha synthesis and release and thereby confers partial protection to endotoxemia. | lld:pubmed |
| pubmed-article:15702085 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15702085 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15702085 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15702085 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15702085 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15702085 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15702085 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15702085 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15702085 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15702085 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15702085 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15702085 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15702085 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15702085 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15702085 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:15702085 | pubmed:issn | 0023-6837 | lld:pubmed |
| pubmed-article:15702085 | pubmed:author | pubmed-author:SchnyderBruno... | lld:pubmed |
| pubmed-article:15702085 | pubmed:author | pubmed-author:Schnyder-Cand... | lld:pubmed |
| pubmed-article:15702085 | pubmed:author | pubmed-author:StewartColin... | lld:pubmed |
| pubmed-article:15702085 | pubmed:author | pubmed-author:PoliValeriaV | lld:pubmed |
| pubmed-article:15702085 | pubmed:author | pubmed-author:RyffelBernhar... | lld:pubmed |
| pubmed-article:15702085 | pubmed:author | pubmed-author:QuesniauxVale... | lld:pubmed |
| pubmed-article:15702085 | pubmed:author | pubmed-author:WeberMarietta... | lld:pubmed |
| pubmed-article:15702085 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15702085 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:15702085 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15702085 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15702085 | pubmed:pagination | 276-84 | lld:pubmed |
| pubmed-article:15702085 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15702085 | pubmed:meshHeading | pubmed-meshheading:15702085... | lld:pubmed |
| pubmed-article:15702085 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15702085 | pubmed:articleTitle | Endogenous leukemia inhibitory factor attenuates endotoxin response. | lld:pubmed |
| pubmed-article:15702085 | pubmed:affiliation | Cancer and Developmental Biology Laboratory, NCI-FCRDC, Frederick, MD, USA. | lld:pubmed |
| pubmed-article:15702085 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15702085 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15702085 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:16878 | entrezgene:pubmed | pubmed-article:15702085 | lld:entrezgene |
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