Linked Life Data

15649445

Source:http://linkedlifedata.com/resource/pubmed/id/15649445

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pubmed-article:15649445pubmed:abstractTextReserpine- and haloperidol-induced orofacial dyskinesia are putative animal models of tardive dyskinesia (TD) whose pathophysiology has been related to free radical generation and oxidative stress. In the present study, the authors induced orofacial dyskinesia by acute reserpine and subchronic haloperidol administration to rats. Reserpine injection (one dose of 1 mg/kg s.c.) every other day for 3 days caused a significant increase in vacuous chewing, tongue protrusion and duration of facial twitching, compared to the control. Haloperidol administration (one dose of 12 mg/kg once a week s.c.) for 4 weeks caused an increase in vacuous chewing, tongue protrusion and duration of facial twitching observed in four weekly evaluations. After the treatments and behavioral observation, glutamate uptake by segments of the brain was analyzed. A decreased glutamate uptake was observed in the subcortical parts of animals treated with reserpine and haloperidol, compared to the control. Importantly, a decrease in glutamate uptake correlates negatively with an increase in the incidence of orofacial diskinesia. These results indicate that early changes in glutamate transport may be related to the development of vacuous chewing movements in rats.lld:pubmed
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pubmed-article:15649445pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:15649445pubmed:articleTitleAcute reserpine and subchronic haloperidol treatments change synaptosomal brain glutamate uptake and elicit orofacial dyskinesia in rats.lld:pubmed
pubmed-article:15649445pubmed:affiliationDepartamento de Fisiologia, Centro de Ciências da Saúde, Bioquimica Toxicologica, 97105-900 Santa Maria RS, Brazil. mariliseeb@yahoo.com.brlld:pubmed
pubmed-article:15649445pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15649445pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:15649445pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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