Linked Life Data

15637977

Source:http://linkedlifedata.com/resource/pubmed/id/15637977

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10 Suppl 1
pubmed:dateCreated
2005-1-10
pubmed:abstractText
The IntelliClean System from Sonicare and Crest combines a rechargeable sonic power toothbrush and a novel liquid toothpaste into one integrated system, providing the opportunity to re-dose with toothpaste during the brushing cycle. The purpose of this study was to investigate cleaning effects from in-mouth re-dosing with toothpaste during the brushing cycle vs conventional bolus dosing. This was a randomized, examiner-blind, six-period, crossover clinical study. Eighteen adult subjects used an experimental integrated system employing either a re-dosing regimen (2 doses at the start of brushing with 1 additional in-mouth dose during the last 30 seconds of brushing [2+1]) or a conventional regimen (2 doses at the start of brushing only [2+0]). Gingival crevicular fluid (GCF) was sampled at the final brushing quadrant from a preselected site in the gingival sulcus using filter strips at baseline and at 4, 15, and 120 minutes postbrushing. Mean change from baseline in the concentrations of total facultative anaerobes (TFAs) and gram-negative anaerobes (GNAs) in the GCF at 120 minutes posttreatment were modeled separately using general linear mixed models. Area under the curve of surfactant (sodium dodecyl sulfate [SDS]) in GCF over 2 hours postbrushing was calculated and modeled using an analysis of variance model. All hypotheses were tested 2-sided at the 5% significance level. Relative to the conventional regimen, the re-dosing (2+1) regimen produced a significantly greater reduction in log10 (TFA colony-forming units [CFU]/microL GCF) after brushing, 0.99+/-0.12 vs 0.65+/-0.12 (mean change +/- standard error), and a significantly greater reduction in log10 (GNA CFU/microL GCF) after brushing, 0.75 +/-0.14 vs 0.45 +/- 0.14. The re-dosing regimen led to significantly more SDS in GCF relative to the conventional regimen over the 2-hour time period. Re-dosing of liquid toothpaste during the brushing cycle with the IntelliClean System leads to a significantly increased cleaning effect, as defined by a reduced bacterial count in GCF, and significantly higher levels of surfactant in the GCF up to 2 hours after the brushing event.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1548-8578
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
21-7
pubmed:dateRevised
2011-11-2
pubmed:meshHeading
pubmed-meshheading:15637977-Adult, pubmed-meshheading:15637977-Analysis of Variance, pubmed-meshheading:15637977-Colony Count, Microbial, pubmed-meshheading:15637977-Cross-Over Studies, pubmed-meshheading:15637977-Dental Devices, Home Care, pubmed-meshheading:15637977-Female, pubmed-meshheading:15637977-Gingival Crevicular Fluid, pubmed-meshheading:15637977-Gram-Negative Anaerobic Bacteria, pubmed-meshheading:15637977-Humans, pubmed-meshheading:15637977-Linear Models, pubmed-meshheading:15637977-Male, pubmed-meshheading:15637977-Silicic Acid, pubmed-meshheading:15637977-Single-Blind Method, pubmed-meshheading:15637977-Sodium Dodecyl Sulfate, pubmed-meshheading:15637977-Sodium Fluoride, pubmed-meshheading:15637977-Sonication, pubmed-meshheading:15637977-Surface-Active Agents, pubmed-meshheading:15637977-Toothbrushing, pubmed-meshheading:15637977-Toothpastes
pubmed:year
2004
pubmed:articleTitle
Pharmacodynamic and pharmacokinetic effects in gingival crevicular fluid from re-dosing during brushing.
pubmed:affiliation
Senior Scientist Procter & Gamble Technical Centres Ltd., Egham, Surrey, UK.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U.S. Gov't