Source:http://linkedlifedata.com/resource/pubmed/id/15623928
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
2004-12-29
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| pubmed:abstractText |
A hydroxyapatite/type I collagen (HAp/Col) composite, aligning hydroxyapatite nano-crystals along collagen molecules, has been synthesized. The biocompatibility, osteoconductivity and efficacy as an rhBMP-2 carrier of this novel biomaterial implanted in the weight-bearing site have been examined. The HAp/Col implants adsorbing 0 or 400 microg/ml of rhBMP-2 were implanted into bone defects of tibiae in 3 beagle dogs and fixed according to the Ilizarov method. As a control, bone defects of 20 mm remaining in 2 beagle dogs and the dogs were allowed to walk using a Ilizarov external skeletal fixator. The radiological and histological findings suggest that the implants induce bone remodeling units and are a superior carrier of rhBMP-2 due to the stimulation of early callus and new bone formation. As a next step, anterior fusion was carried out on 6 beagle dogs with the implants adsorbing 400 microg/ml of rhBMP-2, and 9 dogs with the implants without rhBMP-2. In 3 dogs of the rhBMP-treated group, as well as 6 dogs of the non-rhBMP-treated group, the implant was fixed with a poly-L-lactide plate. Histological and radiographical analysis suggest that enhancement of callus formation and bone bridging by rhBMP-treatment is effective to prevent collapse of the implant.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein 2,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Substitutes,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/Durapatite,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta
|
| pubmed:status |
MEDLINE
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| pubmed:issn |
0959-2989
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
15
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
29-41
|
| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:15623928-Animals,
pubmed-meshheading:15623928-Bone Morphogenetic Protein 2,
pubmed-meshheading:15623928-Bone Morphogenetic Proteins,
pubmed-meshheading:15623928-Bone Substitutes,
pubmed-meshheading:15623928-Cervical Vertebrae,
pubmed-meshheading:15623928-Collagen,
pubmed-meshheading:15623928-Dogs,
pubmed-meshheading:15623928-Drug Delivery Systems,
pubmed-meshheading:15623928-Durapatite,
pubmed-meshheading:15623928-Fracture Healing,
pubmed-meshheading:15623928-Fractures, Bone,
pubmed-meshheading:15623928-Implants, Experimental,
pubmed-meshheading:15623928-Male,
pubmed-meshheading:15623928-Manufactured Materials,
pubmed-meshheading:15623928-Materials Testing,
pubmed-meshheading:15623928-Osseointegration,
pubmed-meshheading:15623928-Osteogenesis,
pubmed-meshheading:15623928-Radius,
pubmed-meshheading:15623928-Spinal Fusion,
pubmed-meshheading:15623928-Transforming Growth Factor beta,
pubmed-meshheading:15623928-Treatment Outcome,
pubmed-meshheading:15623928-Ulna
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
Development of a novel biomaterial, hydroxyapatite/collagen (HAp/Col) composite for medical use.
|
| pubmed:affiliation |
Division of Molecular Tissue Engineering, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8519, Japan. itoso.gene@cmn.tmd.ac.jp
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|