| pubmed-article:15621689 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15621689 | lifeskim:mentions | umls-concept:C0005854 | lld:lifeskim |
| pubmed-article:15621689 | lifeskim:mentions | umls-concept:C0031164 | lld:lifeskim |
| pubmed-article:15621689 | lifeskim:mentions | umls-concept:C0205148 | lld:lifeskim |
| pubmed-article:15621689 | lifeskim:mentions | umls-concept:C1947912 | lld:lifeskim |
| pubmed-article:15621689 | lifeskim:mentions | umls-concept:C1450054 | lld:lifeskim |
| pubmed-article:15621689 | lifeskim:mentions | umls-concept:C0007961 | lld:lifeskim |
| pubmed-article:15621689 | pubmed:issue | 9-10 | lld:pubmed |
| pubmed-article:15621689 | pubmed:dateCreated | 2004-12-28 | lld:pubmed |
| pubmed-article:15621689 | pubmed:abstractText | The blood-brain barrier (BBB) presents both a physical and electrostatic barrier to limit brain permeation of therapeutics. Previous work has demonstrated that nanoparticles (NPs) overcome the physical barrier, but there is little known regarding the effect of NP surface charge on BBB function. Therefore, this work evaluated: (1) effect of neutral, anionic and cationic charged NPs on BBB integrity and (2) NP brain permeability. Methods: Emulsifying wax NPs were prepared from warm oil-in-water microemulsion precursors using neutral, anionic or cationic surfactants to provide the corresponding NP surface charge. NPs were characterized by particle size and zeta potential. BBB integrity and NP brain permeability were evaluated by in situ rat brain perfusion. | lld:pubmed |
| pubmed-article:15621689 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15621689 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15621689 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15621689 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15621689 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15621689 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15621689 | pubmed:issn | 1061-186X | lld:pubmed |
| pubmed-article:15621689 | pubmed:author | pubmed-author:AllenDavid... | lld:pubmed |
| pubmed-article:15621689 | pubmed:author | pubmed-author:MumperRussell... | lld:pubmed |
| pubmed-article:15621689 | pubmed:author | pubmed-author:LockmanPaul... | lld:pubmed |
| pubmed-article:15621689 | pubmed:author | pubmed-author:KoziaraJoanna... | lld:pubmed |
| pubmed-article:15621689 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15621689 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:15621689 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15621689 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15621689 | pubmed:pagination | 635-41 | lld:pubmed |
| pubmed-article:15621689 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:15621689 | pubmed:meshHeading | pubmed-meshheading:15621689... | lld:pubmed |
| pubmed-article:15621689 | pubmed:meshHeading | pubmed-meshheading:15621689... | lld:pubmed |
| pubmed-article:15621689 | pubmed:meshHeading | pubmed-meshheading:15621689... | lld:pubmed |
| pubmed-article:15621689 | pubmed:meshHeading | pubmed-meshheading:15621689... | lld:pubmed |
| pubmed-article:15621689 | pubmed:meshHeading | pubmed-meshheading:15621689... | lld:pubmed |
| pubmed-article:15621689 | pubmed:meshHeading | pubmed-meshheading:15621689... | lld:pubmed |
| pubmed-article:15621689 | pubmed:meshHeading | pubmed-meshheading:15621689... | lld:pubmed |
| pubmed-article:15621689 | pubmed:meshHeading | pubmed-meshheading:15621689... | lld:pubmed |
| pubmed-article:15621689 | pubmed:meshHeading | pubmed-meshheading:15621689... | lld:pubmed |
| pubmed-article:15621689 | pubmed:meshHeading | pubmed-meshheading:15621689... | lld:pubmed |
| pubmed-article:15621689 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15621689 | pubmed:articleTitle | Nanoparticle surface charges alter blood-brain barrier integrity and permeability. | lld:pubmed |
| pubmed-article:15621689 | pubmed:affiliation | Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106-1712, USA. | lld:pubmed |
| pubmed-article:15621689 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15621689 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15621689 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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