| pubmed-article:15557206 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15557206 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:15557206 | lifeskim:mentions | umls-concept:C0020971 | lld:lifeskim |
| pubmed-article:15557206 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:15557206 | lifeskim:mentions | umls-concept:C0026724 | lld:lifeskim |
| pubmed-article:15557206 | lifeskim:mentions | umls-concept:C0442118 | lld:lifeskim |
| pubmed-article:15557206 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:15557206 | lifeskim:mentions | umls-concept:C0020964 | lld:lifeskim |
| pubmed-article:15557206 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:15557206 | lifeskim:mentions | umls-concept:C0040808 | lld:lifeskim |
| pubmed-article:15557206 | lifeskim:mentions | umls-concept:C0205373 | lld:lifeskim |
| pubmed-article:15557206 | lifeskim:mentions | umls-concept:C0443252 | lld:lifeskim |
| pubmed-article:15557206 | lifeskim:mentions | umls-concept:C0913822 | lld:lifeskim |
| pubmed-article:15557206 | lifeskim:mentions | umls-concept:C0913823 | lld:lifeskim |
| pubmed-article:15557206 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:15557206 | pubmed:dateCreated | 2004-11-23 | lld:pubmed |
| pubmed-article:15557206 | pubmed:abstractText | An intranasal DNA vaccine prime followed by a gp41 peptide booster immunization was compared with gp41 peptide and control immunizations. Serum HIV-1-specific IgG and IgA as well as IgA in feces and vaginal and lung secretions were detected after immunizations. Long-term humoral immunity was studied for up to 12 mo after the booster immunization by testing the presence of HIV-1 gp41- and CCR5-specific Abs and IgG/IgA-secreting B lymphocytes in spleen and regional lymph nodes in immunized mice. A long-term IgA-specific response in the intestines, vagina, and lungs was obtained in addition to a systemic immune response. Mice immunized only with gp41 peptides and L3 adjuvant developed a long-term gp41-specific serum IgG response systemically, although over a shorter period (1-9 mo), and long-term mucosal gp41-specific IgA immunity. HIV-1-neutralizing serum Abs were induced that were still present 12 mo after booster immunization. HIV-1 SF2-neutralizing fecal and lung IgA was detectable only in the DNA-primed mouse groups. Intranasal DNA prime followed by one peptide/L3 adjuvant booster immunization, but not a peptide prime followed by a DNA booster, was able to induce B cell memory and HIV-1-neutralizing Abs for at least half of a mouse's life span. | lld:pubmed |
| pubmed-article:15557206 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15557206 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15557206 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:15557206 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15557206 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15557206 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15557206 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15557206 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15557206 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:15557206 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:15557206 | pubmed:author | pubmed-author:OkudaKenjiK | lld:pubmed |
| pubmed-article:15557206 | pubmed:author | pubmed-author:WahrenBrittaB | lld:pubmed |
| pubmed-article:15557206 | pubmed:author | pubmed-author:SchröderUlfU | lld:pubmed |
| pubmed-article:15557206 | pubmed:author | pubmed-author:BrolidenKrist... | lld:pubmed |
| pubmed-article:15557206 | pubmed:author | pubmed-author:DevitoClaudia... | lld:pubmed |
| pubmed-article:15557206 | pubmed:author | pubmed-author:HinkulaJormaJ | lld:pubmed |
| pubmed-article:15557206 | pubmed:author | pubmed-author:ZuberBartekB | lld:pubmed |
| pubmed-article:15557206 | pubmed:author | pubmed-author:BenthinReinho... | lld:pubmed |
| pubmed-article:15557206 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15557206 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:15557206 | pubmed:volume | 173 | lld:pubmed |
| pubmed-article:15557206 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15557206 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15557206 | pubmed:pagination | 7078-89 | lld:pubmed |
| pubmed-article:15557206 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15557206 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15557206 | pubmed:articleTitle | Intranasal HIV-1-gp160-DNA/gp41 peptide prime-boost immunization regimen in mice results in long-term HIV-1 neutralizing humoral mucosal and systemic immunity. | lld:pubmed |
| pubmed-article:15557206 | pubmed:affiliation | Swedish Institute for Infectious Disease Control and Microbiology and Tumorbiology Center, Department of Virology, Karolinska Institute, Solna, Sweden. | lld:pubmed |
| pubmed-article:15557206 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15557206 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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