Source:http://linkedlifedata.com/resource/pubmed/id/15551591
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2004-11-19
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| pubmed:abstractText |
The objective of this investigation was to evaluate small-field-of-view, ultra-high-resolution pinhole collimation for a rotating-camera SPECT system that could be used to image small laboratory animals. Pinhole collimation offers distinct advantages over conventional parallel-hole collimation when used to image small objects. Since geometric sensitivity increases markedly for points close to the pinhole, small-diameter and high-magnification pinhole geometries may be useful for selected imaging tasks when used with large-field-of-view scintillation cameras. The use of large magnifications can minimize the loss of system resolution caused by the intrinsic resolution of the scintillation camera. A pinhole collimator has been designed and built that can be mounted on one of the scintillation cameras of a triple-head SPECT system. Three pinhole inserts with approximate aperture diameters of 0.6, 1.2 and 2.0 mm have been built and can be mounted individually on the collimator housing. When a ramp filter is used with a three-dimensional (3D) filtered backprojection (FBP) algorithm, the three apertures have in-plane SPECT spatial resolutions (FWHM) at 4 cm of 1.5, 1.9 and 2.8 mm, respectively. In-air point source sensitivities at 4 cm from the apertures are 0.9, 2.6 and 5.7 counts s(-1) microCi(-1) (24, 70 and 154 counts s(-1) MBq(-1)) for the 0.6, 1.2 and 2.0 mm apertures, respectively. In vitro image quality was evaluated with a micro-cold-rod phantom and a micro-Defrise phantom using both the 3D FBP algorithm and a 3D maximum likelihood-expectation maximization (ML-EM) algorithm. In vivo image quality was evaluated using two (315 and 325 g) rats. Ultra-high-resolution pinhole SPECT is an inexpensive and simple approach for imaging small animals that can be used with existing rotating-camera SPECT system.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Colloids,
http://linkedlifedata.com/resource/pubmed/chemical/Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Radiopharmaceuticals,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Pertechnetate Tc 99m,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfur
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| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
0031-9155
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
39
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
425-37
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:15551591-Algorithms,
pubmed-meshheading:15551591-Animals,
pubmed-meshheading:15551591-Bone and Bones,
pubmed-meshheading:15551591-Colloids,
pubmed-meshheading:15551591-Female,
pubmed-meshheading:15551591-Gamma Cameras,
pubmed-meshheading:15551591-Humans,
pubmed-meshheading:15551591-Image Processing, Computer-Assisted,
pubmed-meshheading:15551591-Likelihood Functions,
pubmed-meshheading:15551591-Liver,
pubmed-meshheading:15551591-Phantoms, Imaging,
pubmed-meshheading:15551591-Radioisotopes,
pubmed-meshheading:15551591-Radiopharmaceuticals,
pubmed-meshheading:15551591-Rats,
pubmed-meshheading:15551591-Rats, Sprague-Dawley,
pubmed-meshheading:15551591-Sensitivity and Specificity,
pubmed-meshheading:15551591-Sodium Pertechnetate Tc 99m,
pubmed-meshheading:15551591-Sulfur,
pubmed-meshheading:15551591-Tomography, Emission-Computed, Single-Photon
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| pubmed:year |
1994
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| pubmed:articleTitle |
Pinhole collimation for ultra-high-resolution, small-field-of-view SPECT.
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| pubmed:affiliation |
Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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