| pubmed-article:15543342 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15543342 | lifeskim:mentions | umls-concept:C0206194 | lld:lifeskim |
| pubmed-article:15543342 | lifeskim:mentions | umls-concept:C0015176 | lld:lifeskim |
| pubmed-article:15543342 | lifeskim:mentions | umls-concept:C0027051 | lld:lifeskim |
| pubmed-article:15543342 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:15543342 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:15543342 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:15543342 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:15543342 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:15543342 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:15543342 | lifeskim:mentions | umls-concept:C1709269 | lld:lifeskim |
| pubmed-article:15543342 | lifeskim:mentions | umls-concept:C1710133 | lld:lifeskim |
| pubmed-article:15543342 | lifeskim:mentions | umls-concept:C1708943 | lld:lifeskim |
| pubmed-article:15543342 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:15543342 | pubmed:dateCreated | 2004-11-15 | lld:pubmed |
| pubmed-article:15543342 | pubmed:abstractText | Elevated plasma IL-6 levels have been implicated in the pathogenesis of coronary heart disease. We have investigated the association of two polymorphisms in the promoter of IL-6 (-572G>C and -174G>C) with levels of inflammatory markers and risk of myocardial infarction (MI) in a European study of MI survivors and age-matched controls from two high-risk centres in the North of Europe, and two low risk centres in the South. IL-6 and CRP levels were similar in controls in both regions, but were higher in cases. For the -174G>C polymorphism the rare -174C allele showed a regional difference in allele frequency, being more common in the North European group (0.43 vs 0.28; p < 0.0005), where -174C allele carriers showed an apparent reduced risk of MI compared to -174GG homozygotes (OR 0.53, 95%CI 0.32, 0.86). No such effect was observed in the South or with the -572G>C in either group. Neither genotype was associated with a significant effect on plasma IL-6 levels in either cases or controls. Furthermore, no regional difference was observed in the frequency of the -572G>C SNP, suggesting that these polymorphisms are unlikely to be contributing to the observed increased risk of cardiovascular disease in Northern Europe. | lld:pubmed |
| pubmed-article:15543342 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15543342 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15543342 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15543342 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15543342 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15543342 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15543342 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:15543342 | pubmed:issn | 0340-6245 | lld:pubmed |
| pubmed-article:15543342 | pubmed:author | pubmed-author:AillaudM FMF | lld:pubmed |
| pubmed-article:15543342 | pubmed:author | pubmed-author:LuongL ALA | lld:pubmed |
| pubmed-article:15543342 | pubmed:author | pubmed-author:HaweEE | lld:pubmed |
| pubmed-article:15543342 | pubmed:author | pubmed-author:Juhan-VagueIr... | lld:pubmed |
| pubmed-article:15543342 | pubmed:author | pubmed-author:YudkinJohn... | lld:pubmed |
| pubmed-article:15543342 | pubmed:author | pubmed-author:TremoliElenaE | lld:pubmed |
| pubmed-article:15543342 | pubmed:author | pubmed-author:MargaglioneMa... | lld:pubmed |
| pubmed-article:15543342 | pubmed:author | pubmed-author:HIFMECH... | lld:pubmed |
| pubmed-article:15543342 | pubmed:author | pubmed-author:TornvallPerP | lld:pubmed |
| pubmed-article:15543342 | pubmed:author | pubmed-author:LundmanPiaP | lld:pubmed |
| pubmed-article:15543342 | pubmed:author | pubmed-author:Mohamed-AliVi... | lld:pubmed |
| pubmed-article:15543342 | pubmed:author | pubmed-author:HumphriesStep... | lld:pubmed |
| pubmed-article:15543342 | pubmed:author | pubmed-author:di... | lld:pubmed |
| pubmed-article:15543342 | pubmed:author | pubmed-author:KelbermanDani... | lld:pubmed |
| pubmed-article:15543342 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15543342 | pubmed:volume | 92 | lld:pubmed |
| pubmed-article:15543342 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15543342 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15543342 | pubmed:pagination | 1122-8 | lld:pubmed |
| pubmed-article:15543342 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:15543342 | pubmed:meshHeading | pubmed-meshheading:15543342... | lld:pubmed |
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| pubmed-article:15543342 | pubmed:meshHeading | pubmed-meshheading:15543342... | lld:pubmed |
| pubmed-article:15543342 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15543342 | pubmed:articleTitle | Effect of Interleukin-6 promoter polymorphisms in survivors of myocardial infarction and matched controls in the North and South of Europe. The HIFMECH Study. | lld:pubmed |
| pubmed-article:15543342 | pubmed:affiliation | Centre for Cardiovascular Genetics, Department of Medicine, Royal Free and University College London Medical School, UK. | lld:pubmed |
| pubmed-article:15543342 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15543342 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:3569 | entrezgene:pubmed | pubmed-article:15543342 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15543342 | lld:entrezgene |
