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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2004-11-15
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pubmed:abstractText |
Prostate cancer cells secrete the unique protease human glandular kallikrein 2 (hK2) that represents a target for proteolytic activation of cytotoxic prodrugs. The objective of this study was to identify hK2-selective peptide substrates that could be coupled to a cytotoxic analogue of thapsigargin, a potent inhibitor of the sarcoplasmic/endoplasmic reticulum calcium ATPase pump that induces cell proliferation-independent apoptosis through dysregulation of intracellular calcium levels.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1535-7163
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1439-50
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15542783-Amino Acid Sequence,
pubmed-meshheading:15542783-Animals,
pubmed-meshheading:15542783-Antineoplastic Agents,
pubmed-meshheading:15542783-Cathepsin B,
pubmed-meshheading:15542783-Cell Line, Tumor,
pubmed-meshheading:15542783-Drug Evaluation, Preclinical,
pubmed-meshheading:15542783-Humans,
pubmed-meshheading:15542783-Hydrolysis,
pubmed-meshheading:15542783-Male,
pubmed-meshheading:15542783-Mice,
pubmed-meshheading:15542783-Molecular Structure,
pubmed-meshheading:15542783-Peptide Library,
pubmed-meshheading:15542783-Peptides,
pubmed-meshheading:15542783-Prodrugs,
pubmed-meshheading:15542783-Prostatic Neoplasms,
pubmed-meshheading:15542783-Substrate Specificity,
pubmed-meshheading:15542783-Thapsigargin,
pubmed-meshheading:15542783-Tissue Kallikreins,
pubmed-meshheading:15542783-Trypsin
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pubmed:year |
2004
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pubmed:articleTitle |
Screening a combinatorial peptide library to develop a human glandular kallikrein 2-activated prodrug as targeted therapy for prostate cancer.
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pubmed:affiliation |
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Bunting Blaustein Cancer Research Building, 1650 Orleans Street, Baltimore, MD 21231, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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