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pubmed-article:15538081pubmed:abstractTextHereditary palmoplantar keratoderma, a well-known clinical entity, is illustrated through a familial report of an unmarried young man who is the product of a consanguineous marriage (paternal and maternal grandmothers were sisters). The lesions were characterized by immense yellow waxy thickening of the skin surrounded by erythematous border (halo) and fissures/cracks associated with extensive scaling of the palms and soles. The lesions were bilateral and symmetrical. These features were supported by orthokeratotic hyperkeratosis hypergranulosis and acanthosis in hematoxylin-eosin stained tissue sections prepared from the soles. Mycelia/spores could not be identified on Periodic acid-Schiff (PAS) reaction. An autosomal dominant trait was revealed through family pedigree. An abridged update to recap the current status is highlighted.lld:pubmed
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pubmed-article:15538081pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:15538081pubmed:articleTitleHereditary palmoplantar (epidermolytic) keratoderma: illustration through a familial report.lld:pubmed
pubmed-article:15538081pubmed:affiliationDermato-Venereology (Skin/VD) Centre, Sehgal Nursing Home, Panchwati, Azadpur, Delhi, India. drsehgal@ndf.vsnl.net.in.lld:pubmed
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