Source:http://linkedlifedata.com/resource/pubmed/id/15517366
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0007134,
umls-concept:C0017262,
umls-concept:C0027627,
umls-concept:C0185117,
umls-concept:C0205225,
umls-concept:C0205460,
umls-concept:C0220922,
umls-concept:C0237881,
umls-concept:C0449851,
umls-concept:C0475358,
umls-concept:C0598086,
umls-concept:C0598388,
umls-concept:C0750502,
umls-concept:C0936012,
umls-concept:C1335831,
umls-concept:C1415887,
umls-concept:C1419040,
umls-concept:C1420433,
umls-concept:C1424666,
umls-concept:C1519522,
umls-concept:C2911684
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| pubmed:issue |
6
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| pubmed:dateCreated |
2004-12-3
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| pubmed:abstractText |
p27 (p27/kip1) is involved in cell-cycle control, and loss of p27 expression may result in tumour development and/or progression. Association with Skp2 targets p27 for degradation. Using a tissue microarray technique, 171 primary renal cell carcinomas (RCCs) and 58 RCC metastases were immunostained for p27 and Skp2. p27 Immunoreactivity was noted in 83 of 129 (64%) clear cell, 6 of 22 (27%) chromophobe and 15 of 20 (75%) papillary tumours as well as 44 of 58 (76%) metastases. In clear cell cancers, high p27 expression (> or =50% of tumour cells) decreased with rising tumour stage (50% pT1/pT2 versus 20% pT3; P<0.001) and grade (44% G1/G2 versus 21% G3/G4; P=0.008). None of 22 chromophobe cancers showed high expression in contrast to 46 of 129 (36%) clear cell tumours (P<0.001). Skp2 expression was noted in 8 of 129 (6%) clear cell cancers and 11 of 55 (20%) metastases (P=0.008). Immunoreactivity increased with rising tumour stage (1% pT1/pT2 versus 11% pT3; P=0.03) and grade (1% G1/G2 versus 15% G3/G4; P=0.004) and was associated with sarcomatoid morphology (P<0.001). In multivariate analysis, patients with low p27 expression and Skp2 immunoreactivity in clear cell cancers had a less favourable outcome. In conclusion, p27 and Skp2 proved to be additional biomarkers in renal cancer pathology with both prognostic and diagnostic impact.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/S-Phase Kinase-Associated Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins
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| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
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| pubmed:issn |
0945-6317
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
445
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
631-6
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| pubmed:dateRevised |
2005-11-17
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| pubmed:meshHeading |
pubmed-meshheading:15517366-Adult,
pubmed-meshheading:15517366-Aged,
pubmed-meshheading:15517366-Aged, 80 and over,
pubmed-meshheading:15517366-Carcinoma, Renal Cell,
pubmed-meshheading:15517366-Cell Cycle Proteins,
pubmed-meshheading:15517366-Cyclin-Dependent Kinase Inhibitor p27,
pubmed-meshheading:15517366-Disease-Free Survival,
pubmed-meshheading:15517366-Female,
pubmed-meshheading:15517366-Humans,
pubmed-meshheading:15517366-Immunohistochemistry,
pubmed-meshheading:15517366-Kidney Neoplasms,
pubmed-meshheading:15517366-Male,
pubmed-meshheading:15517366-Middle Aged,
pubmed-meshheading:15517366-S-Phase Kinase-Associated Proteins,
pubmed-meshheading:15517366-Tissue Array Analysis,
pubmed-meshheading:15517366-Tumor Suppressor Proteins
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| pubmed:year |
2004
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| pubmed:articleTitle |
Biological significance of p27 and Skp2 expression in renal cell carcinoma. A systematic analysis of primary and metastatic tumour tissues using a tissue microarray technique.
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| pubmed:affiliation |
Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036 Graz, Austria. cord.langner@meduni-graz.at
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| pubmed:publicationType |
Journal Article
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