Source:http://linkedlifedata.com/resource/pubmed/id/15515090
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
11
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pubmed:dateCreated |
2004-11-10
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pubmed:abstractText |
The glycosyltransferase gene lanGT3, involved in the biosynthesis of the angucyclic antibiotic landomycin A, has been characterised by targeted gene deletion. A lanGT3 mutant was shown to produce landomycin E, which consists of a trisaccharide side chain attached to the polyketide moiety. Expression of lanGT3 in the mutant restored landomycin A production. Our results indicate that LanGT3 is responsible for the transfer of the fourth sugar during landomycin A biosynthesis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1439-4227
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1567-70
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15515090-Aminoglycosides,
pubmed-meshheading:15515090-Anti-Bacterial Agents,
pubmed-meshheading:15515090-Carbohydrate Sequence,
pubmed-meshheading:15515090-Escherichia coli,
pubmed-meshheading:15515090-Gene Expression Regulation, Bacterial,
pubmed-meshheading:15515090-Glycosyltransferases,
pubmed-meshheading:15515090-Molecular Sequence Data,
pubmed-meshheading:15515090-Mutation
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pubmed:year |
2004
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pubmed:articleTitle |
Function of lanGT3, a glycosyltransferase gene involved in landomycin A biosynthesis.
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pubmed:affiliation |
Albert-Ludwigs-Universität, Institut für Pharmazeutische Wissenschaften, Stefan-Meier-Strasse 19, 79104 Freiburg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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