Linked Life Data

15479090

Source:http://linkedlifedata.com/resource/pubmed/id/15479090

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
41
pubmed:dateCreated
2004-10-13
pubmed:abstractText
Many pathogens that infect humans use cell surface carbohydrates as receptors to facilitate cell-cell adhesion. The hallmark of these interactions is their multivalency, or the simultaneous occurrence of multiple interactions. We have used a carbohydrate-functionalized fluorescent polymer, which displays many carbohydrate ligands on a single polymer chain, to allow for multivalent detection of pathogens. Incubation of a mannose-functionalized polymer with Escherichia coli yields brightly fluorescent aggregates of bacteria. These results show that carbohydrate-functionalized fluorescent polymers are a versatile detection method for bacteria. Future design of detectors for other pathogens only requires information on the carbohydrates bound by the organisms, which has been exhaustively reported in the literature.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0002-7863
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
126
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
13343-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Detection of bacteria with carbohydrate-functionalized fluorescent polymers.
pubmed:affiliation
Laboratory for Organic Chemistry, Swiss Federal Institute of Technology Zürich, ETH Hönggerberg HCI F315 Wolfgang-Pauli-Strasse 10, 8093 Zürich, Switzerland.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't