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rdf:type |
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lifeskim:mentions |
umls-concept:C0024880,
umls-concept:C0039194,
umls-concept:C0040421,
umls-concept:C0086418,
umls-concept:C0258911,
umls-concept:C0439851,
umls-concept:C1155046,
umls-concept:C1420812,
umls-concept:C1552596,
umls-concept:C1707455,
umls-concept:C1947931,
umls-concept:C1956267
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pubmed:issue |
8
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pubmed:dateCreated |
2004-10-7
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pubmed:abstractText |
Mast cells (MCs) are the primary effector cells in allergic reactions and have also been found to activate T cells and to reside in close physical proximity to T cells. However, the molecular mechanisms involved in the MC-T cell interaction remain unclear. We hypothesized that human tonsillar MCs, which locate in the interfollicular areas, might interact with T cells. Thus, we first established a culture system of human tonsillar MCs and then compared gene expression profiles of tonsillar MCs with that of lung MCs before and after aggregation of FcepsilonRI by using high-density oligonucleotide probe arrays. Here we show that resting tonsillar MCs, when compared with lung MCs, revealed significantly higher expression levels for CC chemokines (CCL3 and 4), which recruit T cells, and for TNFR superfamilies (OX40 ligand and 4-1BB ligand), which induce proliferation of T cells. After aggregation of FcepsilonRI, not only tonsillar MCs but also lung MCs up-regulated the expression of these molecules. We confirmed that T cell proliferation is induced in direct cross-talk by the MC surface molecule OX40 ligand. These results suggest that human MCs may play important roles in adaptive immunity through the T cell responses.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-1BB Ligand,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD137,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/OX40 Ligand,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgE,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Nerve Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, OX40,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/TNFRSF4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TNFRSF9 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TNFSF4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TNFSF9 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
173
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5247-57
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15470070-4-1BB Ligand,
pubmed-meshheading:15470070-Antigens, CD,
pubmed-meshheading:15470070-Antigens, CD137,
pubmed-meshheading:15470070-Cells, Cultured,
pubmed-meshheading:15470070-Coculture Techniques,
pubmed-meshheading:15470070-Gene Expression Profiling,
pubmed-meshheading:15470070-Humans,
pubmed-meshheading:15470070-Lung,
pubmed-meshheading:15470070-Lymphocyte Activation,
pubmed-meshheading:15470070-Mast Cells,
pubmed-meshheading:15470070-Membrane Glycoproteins,
pubmed-meshheading:15470070-OX40 Ligand,
pubmed-meshheading:15470070-Palatine Tonsil,
pubmed-meshheading:15470070-Receptors, IgE,
pubmed-meshheading:15470070-Receptors, Nerve Growth Factor,
pubmed-meshheading:15470070-Receptors, OX40,
pubmed-meshheading:15470070-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:15470070-T-Lymphocytes,
pubmed-meshheading:15470070-Tumor Necrosis Factor-alpha
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pubmed:year |
2004
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pubmed:articleTitle |
T cell proliferation by direct cross-talk between OX40 ligand on human mast cells and OX40 on human T cells: comparison of gene expression profiles between human tonsillar and lung-cultured mast cells.
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pubmed:affiliation |
Research Unit for Allergy Transcriptome, Research Center for Allergy and Immunology, The Institute of Physical and Chemical Research, (RIKEN) Yokohama Institute, Suehiro-cho, Tsurumi-ku, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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