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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2004-10-6
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pubmed:abstractText |
Dilated cardiomyopathy (DCM) is one of the most common causes of heart failure among children and is often progressive despite maximal medical therapy. Heart failure is characterized by a number of neurohormonal abnormalities, including derangements in the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) signaling axis. Decreased serum levels of GH, which acts on cardiac myocytes primarily through IGF-1, are associated with impaired myocardial growth and function, which can be improved with restoration of GH/IGF-1 homeostasis. In animal models and among human adults with heart failure attributable to DCM, treatment with GH results in acquisition of left ventricular (LV) mass and improved LV function, through a combination of mechanisms. We undertook this study to determine the effects of recombinant human GH on LV function and mass among children with stable LV dysfunction attributable to DCM.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1098-4275
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
114
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e452-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15466071-Adolescent,
pubmed-meshheading:15466071-Cardiomyopathy, Dilated,
pubmed-meshheading:15466071-Child,
pubmed-meshheading:15466071-Child, Preschool,
pubmed-meshheading:15466071-Cross-Over Studies,
pubmed-meshheading:15466071-Female,
pubmed-meshheading:15466071-Growth,
pubmed-meshheading:15466071-Human Growth Hormone,
pubmed-meshheading:15466071-Humans,
pubmed-meshheading:15466071-Infant,
pubmed-meshheading:15466071-Insulin-Like Growth Factor Binding Protein 3,
pubmed-meshheading:15466071-Insulin-Like Growth Factor I,
pubmed-meshheading:15466071-Male,
pubmed-meshheading:15466071-Recombinant Proteins,
pubmed-meshheading:15466071-Single-Blind Method,
pubmed-meshheading:15466071-Ventricular Dysfunction, Left,
pubmed-meshheading:15466071-Ventricular Function, Left
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pubmed:year |
2004
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pubmed:articleTitle |
Recombinant human growth hormone treatment for dilated cardiomyopathy in children.
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pubmed:affiliation |
Department of Cardiology, Children's Hospital, 300 Longwood Ave, Boston, MA 02115, USA. doff.mcelhinney@cardio.chboston.org
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Randomized Controlled Trial
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