Source:http://linkedlifedata.com/resource/pubmed/id/15447460
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
|
pubmed:dateCreated |
2004-9-27
|
pubmed:abstractText |
Recent experiments indicate that double-stranded DNA molecules of approximately 100 base pairs in length have a probability of cyclization which is up to 10(5) times larger than that expected based on the known bending modulus of the double-helix. We argue that for short molecules, the formation of a few base pairs of single-stranded DNA can provide a "flexible hinge" that facilitates loop formation. A detailed calculation shows that this mechanism explains the experimental data.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Sep
|
pubmed:issn |
0031-9007
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
3
|
pubmed:volume |
93
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
108108
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:15447460-Base Sequence,
pubmed-meshheading:15447460-Computer Simulation,
pubmed-meshheading:15447460-Cyclization,
pubmed-meshheading:15447460-DNA,
pubmed-meshheading:15447460-DNA, Single-Stranded,
pubmed-meshheading:15447460-Elasticity,
pubmed-meshheading:15447460-Models, Chemical,
pubmed-meshheading:15447460-Models, Molecular,
pubmed-meshheading:15447460-Molecular Sequence Data,
pubmed-meshheading:15447460-Nucleic Acid Conformation
|
pubmed:year |
2004
|
pubmed:articleTitle |
Localized single-stranded bubble mechanism for cyclization of short double helix DNA.
|
pubmed:affiliation |
Department of Physics,University of Illinois at Chicago, 845 West Taylor Street, Chicago Illinois 60607-7059, USA.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, Non-P.H.S.,
Evaluation Studies,
Validation Studies
|