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pubmed-article:15373480pubmed:abstractTextThe direct proline-catalyzed asymmetric alpha-aminoxylation of aldehydes and ketones has been developed using nitrosobenzene as an oxygen source, affording alpha-anilinoxy-aldehydes and -ketones with excellent enantioselectivity. Reaction conditions have been optimized, and low temperature (-20 degrees C) was found to be a key for the successful alpha-aminoxylation of aldehydes, while slow addition of nitrosobenzene is essential for that of ketones. The scope of the reaction is presented.lld:pubmed
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pubmed-article:15373480pubmed:authorpubmed-author:HayashiYujiro...lld:pubmed
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pubmed-article:15373480pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:15373480pubmed:articleTitleDirect proline-catalyzed asymmetric alpha-aminoxylation of aldehydes and ketones.lld:pubmed
pubmed-article:15373480pubmed:affiliationDepartment of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan. hayashi@ci.kagu.tus.ac.jplld:pubmed
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