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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
2004-9-17
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pubmed:abstractText |
The direct proline-catalyzed asymmetric alpha-aminoxylation of aldehydes and ketones has been developed using nitrosobenzene as an oxygen source, affording alpha-anilinoxy-aldehydes and -ketones with excellent enantioselectivity. Reaction conditions have been optimized, and low temperature (-20 degrees C) was found to be a key for the successful alpha-aminoxylation of aldehydes, while slow addition of nitrosobenzene is essential for that of ketones. The scope of the reaction is presented.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-3263
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
69
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5966-73
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15373480-Aldehydes,
pubmed-meshheading:15373480-Catalysis,
pubmed-meshheading:15373480-Ketones,
pubmed-meshheading:15373480-Models, Molecular,
pubmed-meshheading:15373480-Molecular Structure,
pubmed-meshheading:15373480-Nitroso Compounds,
pubmed-meshheading:15373480-Oxygen,
pubmed-meshheading:15373480-Proline,
pubmed-meshheading:15373480-Stereoisomerism,
pubmed-meshheading:15373480-Temperature
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pubmed:year |
2004
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pubmed:articleTitle |
Direct proline-catalyzed asymmetric alpha-aminoxylation of aldehydes and ketones.
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pubmed:affiliation |
Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan. hayashi@ci.kagu.tus.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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