| pubmed-article:15371446 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15371446 | lifeskim:mentions | umls-concept:C0033554 | lld:lifeskim |
| pubmed-article:15371446 | lifeskim:mentions | umls-concept:C0288472 | lld:lifeskim |
| pubmed-article:15371446 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:15371446 | lifeskim:mentions | umls-concept:C0085177 | lld:lifeskim |
| pubmed-article:15371446 | lifeskim:mentions | umls-concept:C0249197 | lld:lifeskim |
| pubmed-article:15371446 | lifeskim:mentions | umls-concept:C1414371 | lld:lifeskim |
| pubmed-article:15371446 | lifeskim:mentions | umls-concept:C1420626 | lld:lifeskim |
| pubmed-article:15371446 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:15371446 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:15371446 | pubmed:issue | 47 | lld:pubmed |
| pubmed-article:15371446 | pubmed:dateCreated | 2004-11-15 | lld:pubmed |
| pubmed-article:15371446 | pubmed:abstractText | Treatment with the stress agent prostaglandin A2 (PGA2) induces expression of the cyclin-dependent kinase inhibitor p21. Here, we present evidence that p21 expression increases through PGA2-triggered stabilization of the p21 mRNA and further show that these events require the mitogen-activated protein (MAP) kinase ERK. Binding experiments using either endogenous p21 mRNA or in vitro-labeled p21 transcripts revealed a specific PGA2-dependent association of the p21 mRNA with the RNA-binding protein HuR. Interestingly, although inhibition of the ERK pathway did not prevent the PGA2-triggered increase in cytoplasmic HuR, it did impair the formation of endogenous and in vitro [HuR-p21 mRNA] complexes and further prevented the PGA2-mediated stabilization of the p21 mRNA, suggesting that ERK-mediated events were required for binding HuR to the p21 mRNA and preventing its decay. RNA interference-based knockdown of HuR abundance further served to demonstrate the contribution of HuR-mediated p21 mRNA stabilization toward enhancing p21 expression after PGA2 treatment. Collectively, our results indicate that PGA2 stabilizes the p21 mRNA through an ERK-independent increase in cytoplasmic HuR levels and an ERK-dependent association of HuR with the p21 mRNA. | lld:pubmed |
| pubmed-article:15371446 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15371446 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15371446 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15371446 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15371446 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15371446 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15371446 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15371446 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15371446 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15371446 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15371446 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15371446 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15371446 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15371446 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15371446 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15371446 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15371446 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15371446 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15371446 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15371446 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15371446 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15371446 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:15371446 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:15371446 | pubmed:author | pubmed-author:ChengHepingH | lld:pubmed |
| pubmed-article:15371446 | pubmed:author | pubmed-author:GorospeMyriam... | lld:pubmed |
| pubmed-article:15371446 | pubmed:author | pubmed-author:WangWengongW | lld:pubmed |
| pubmed-article:15371446 | pubmed:author | pubmed-author:FanJinshuiJ | lld:pubmed |
| pubmed-article:15371446 | pubmed:author | pubmed-author:YangXiaolingX | lld:pubmed |
| pubmed-article:15371446 | pubmed:author | pubmed-author:YangDongmeiD | lld:pubmed |
| pubmed-article:15371446 | pubmed:author | pubmed-author:LalAshishA | lld:pubmed |
| pubmed-article:15371446 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15371446 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:15371446 | pubmed:volume | 279 | lld:pubmed |
| pubmed-article:15371446 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15371446 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15371446 | pubmed:pagination | 49298-306 | lld:pubmed |
| pubmed-article:15371446 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:15371446 | pubmed:meshHeading | pubmed-meshheading:15371446... | lld:pubmed |
| pubmed-article:15371446 | pubmed:meshHeading | pubmed-meshheading:15371446... | lld:pubmed |
| pubmed-article:15371446 | pubmed:meshHeading | pubmed-meshheading:15371446... | lld:pubmed |
| pubmed-article:15371446 | pubmed:meshHeading | pubmed-meshheading:15371446... | lld:pubmed |
| pubmed-article:15371446 | pubmed:meshHeading | pubmed-meshheading:15371446... | lld:pubmed |
| pubmed-article:15371446 | pubmed:meshHeading | pubmed-meshheading:15371446... | lld:pubmed |
| pubmed-article:15371446 | pubmed:meshHeading | pubmed-meshheading:15371446... | lld:pubmed |
| pubmed-article:15371446 | pubmed:meshHeading | pubmed-meshheading:15371446... | lld:pubmed |
| pubmed-article:15371446 | pubmed:meshHeading | pubmed-meshheading:15371446... | lld:pubmed |
| pubmed-article:15371446 | pubmed:meshHeading | pubmed-meshheading:15371446... | lld:pubmed |
| pubmed-article:15371446 | pubmed:meshHeading | pubmed-meshheading:15371446... | lld:pubmed |
| pubmed-article:15371446 | pubmed:meshHeading | pubmed-meshheading:15371446... | lld:pubmed |
| pubmed-article:15371446 | pubmed:meshHeading | pubmed-meshheading:15371446... | lld:pubmed |
| pubmed-article:15371446 | pubmed:meshHeading | pubmed-meshheading:15371446... | lld:pubmed |
| pubmed-article:15371446 | pubmed:meshHeading | pubmed-meshheading:15371446... | lld:pubmed |
| pubmed-article:15371446 | pubmed:meshHeading | pubmed-meshheading:15371446... | lld:pubmed |
| pubmed-article:15371446 | pubmed:meshHeading | pubmed-meshheading:15371446... | lld:pubmed |
| pubmed-article:15371446 | pubmed:meshHeading | pubmed-meshheading:15371446... | lld:pubmed |
| pubmed-article:15371446 | pubmed:meshHeading | pubmed-meshheading:15371446... | lld:pubmed |
| pubmed-article:15371446 | pubmed:meshHeading | pubmed-meshheading:15371446... | lld:pubmed |
| pubmed-article:15371446 | pubmed:meshHeading | pubmed-meshheading:15371446... | lld:pubmed |
| pubmed-article:15371446 | pubmed:meshHeading | pubmed-meshheading:15371446... | lld:pubmed |
| pubmed-article:15371446 | pubmed:meshHeading | pubmed-meshheading:15371446... | lld:pubmed |
| pubmed-article:15371446 | pubmed:meshHeading | pubmed-meshheading:15371446... | lld:pubmed |
| pubmed-article:15371446 | pubmed:meshHeading | pubmed-meshheading:15371446... | lld:pubmed |
| pubmed-article:15371446 | pubmed:meshHeading | pubmed-meshheading:15371446... | lld:pubmed |
| pubmed-article:15371446 | pubmed:meshHeading | pubmed-meshheading:15371446... | lld:pubmed |
| pubmed-article:15371446 | pubmed:meshHeading | pubmed-meshheading:15371446... | lld:pubmed |
| pubmed-article:15371446 | pubmed:meshHeading | pubmed-meshheading:15371446... | lld:pubmed |
| pubmed-article:15371446 | pubmed:meshHeading | pubmed-meshheading:15371446... | lld:pubmed |
| pubmed-article:15371446 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15371446 | pubmed:articleTitle | Prostaglandin A2-mediated stabilization of p21 mRNA through an ERK-dependent pathway requiring the RNA-binding protein HuR. | lld:pubmed |
| pubmed-article:15371446 | pubmed:affiliation | Laboratory of Cellular and Molecular Biology, NIA, National Institutes of Health, Baltimore, MD 21224, USA. | lld:pubmed |
| pubmed-article:15371446 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:1026 | entrezgene:pubmed | pubmed-article:15371446 | lld:entrezgene |
| entrez-gene:1994 | entrezgene:pubmed | pubmed-article:15371446 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15371446 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15371446 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15371446 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15371446 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15371446 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15371446 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15371446 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15371446 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15371446 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15371446 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15371446 | lld:pubmed |
