Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
18
pubmed:dateCreated
2004-9-16
pubmed:abstractText
A cross-sectional study was conducted to evaluate the relationship between exposure to selected organochlorine pesticides (OCP) (p,p'-DDT, p',p'-DDE, dieldrin, hexachlorobenzene, beta-hexachlorocyclohexane [beta-HCH], oxychlordane, trans' nonachlor) and age at natural menopause in a sample of 219 menopausal women participating in the Hispanic Health and Nutrition Examination Survey in 1982-1984. Information on age at menopause, reproductive history, demographic variables, and potential confounding variables was collected via interview. Analysis of variance was employed to compare adjusted mean age at natural menopause among women by category of serum OCP level. Serum levels of p,p'-DDT, p,p'-DDE, beta-HCH, and trans-nonachlor were associated with a younger age at menopause. In particular, women with exposure levels in the highest exposure categories (serum p,p'-DDT > or = 6ppb, beta-HCH > or = 4ppb, or trans-nonachlor > or = 2ppb) had an adjusted mean age at menopause on average 5.7, 3.4, and 5.2 yr earlier, respectively, than women with serum levels of these pesticides below the detection limit. Women with serum p,p'-DDE levels greater than 23.6 ppb (highest quintile) had an adjusted mean age at menopause 1.7 yr earlier than women with serump,p'-DDE levels less than 5.5 ppb (lowest quintile). However, no consistent dose-response effect was apparent across low, medium, and high exposure categories. Interactions were detected for p,p'-DDT in combination with beta-HCH, trans-nonachlor, or oxychlordane, as well as beta-HCH in combination with oxychlordane.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1528-7394
pubmed:author
pubmed:copyrightInfo
Copyright Taylor & Francis Inc.
pubmed:issnType
Print
pubmed:day
24
pubmed:volume
67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1407-22
pubmed:dateRevised
2006-2-16
pubmed:meshHeading
pubmed-meshheading:15371229-Adolescent, pubmed-meshheading:15371229-Adult, pubmed-meshheading:15371229-Age Factors, pubmed-meshheading:15371229-Aged, pubmed-meshheading:15371229-Analysis of Variance, pubmed-meshheading:15371229-Chlordan, pubmed-meshheading:15371229-Cross-Sectional Studies, pubmed-meshheading:15371229-DDT, pubmed-meshheading:15371229-Dichlorodiphenyl Dichloroethylene, pubmed-meshheading:15371229-Dieldrin, pubmed-meshheading:15371229-Drug Interactions, pubmed-meshheading:15371229-Environmental Exposure, pubmed-meshheading:15371229-Environmental Monitoring, pubmed-meshheading:15371229-Epidemiologic Studies, pubmed-meshheading:15371229-Female, pubmed-meshheading:15371229-Hexachlorobenzene, pubmed-meshheading:15371229-Hispanic Americans, pubmed-meshheading:15371229-Humans, pubmed-meshheading:15371229-Hydrocarbons, Chlorinated, pubmed-meshheading:15371229-Insecticides, pubmed-meshheading:15371229-Life Style, pubmed-meshheading:15371229-Lindane, pubmed-meshheading:15371229-Menopause, pubmed-meshheading:15371229-Middle Aged, pubmed-meshheading:15371229-Nutrition Surveys, pubmed-meshheading:15371229-Questionnaires, pubmed-meshheading:15371229-Reproductive History, pubmed-meshheading:15371229-Risk Factors, pubmed-meshheading:15371229-United States, pubmed-meshheading:15371229-Women
pubmed:year
2004
pubmed:articleTitle
Age at natural menopause and exposure to organochlorine pesticides in Hispanic women.
pubmed:affiliation
U.S. Department of Agriculture, Animal Plant Health Inspection Service, Veterinary Services, Centers for Epidemiology and Animal Health, Fort Collins, Colorado 80526-8117, USA. judy.e.akkina@usda.gov
pubmed:publicationType
Journal Article