| pubmed-article:15358679 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15358679 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:15358679 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:15358679 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:15358679 | lifeskim:mentions | umls-concept:C1519090 | lld:lifeskim |
| pubmed-article:15358679 | lifeskim:mentions | umls-concept:C0028351 | lld:lifeskim |
| pubmed-article:15358679 | lifeskim:mentions | umls-concept:C0034785 | lld:lifeskim |
| pubmed-article:15358679 | lifeskim:mentions | umls-concept:C0752312 | lld:lifeskim |
| pubmed-article:15358679 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:15358679 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15358679 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:15358679 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:15358679 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:15358679 | pubmed:dateCreated | 2004-11-16 | lld:pubmed |
| pubmed-article:15358679 | pubmed:abstractText | In this study, we investigated the mechanisms through which norepinephrine (NE) regulates MAPK phosphatase-1 (MKP-1) expression in rat pinealocytes. Stimulation with NE (a mixed alpha- and beta-adrenergic agonist) caused a rapid increase in MKP-1 mRNA and protein that peaked around 1 h post stimulation, and the response was sustained for at least 4 h. Selective activation of beta-adrenergic receptors with isoproterenol for 1 h caused a similar increase in MKP-1 mRNA and protein as observed with NE, but at 3 h, the isoproterenol response was much lower relative to NE. In contrast, selective activation of alpha-adrenergic receptors caused only small increases in MKP-1 mRNA and protein and appeared to function primarily in prolonging the beta-adrenergic-stimulated responses. In NE-stimulated pinealocytes, blockade of beta-adrenergic receptors caused a rapid reduction in MKP-1 mRNA, but it had a minimal effect on MKP-1 protein. In contrast, blockade of alpha-adrenergic receptors specifically reduced NE-induced MKP-1 protein but not mRNA. At the postreceptor level, treatment with dibutyryl cAMP caused parallel increases in MKP-1 mRNA and protein. However, treatment with a protein kinase C activator caused a significant increase in MKP-1 protein but had little effect on MKP-1 mRNA. Together, these results suggest that, in rat pinealocytes, NE activates the beta-adrenergic receptor --> protein kinase A pathway to induce transcription and translation of MKP-1 expression and the alpha-adrenergic receptor --> protein kinase C pathway to prolong the stimulated responses through increased stability of the MKP-1 protein. | lld:pubmed |
| pubmed-article:15358679 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15358679 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15358679 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:15358679 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15358679 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15358679 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15358679 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:15358679 | pubmed:issn | 0013-7227 | lld:pubmed |
| pubmed-article:15358679 | pubmed:author | pubmed-author:PriceDonald... | lld:pubmed |
| pubmed-article:15358679 | pubmed:author | pubmed-author:ChikConstance... | lld:pubmed |
| pubmed-article:15358679 | pubmed:author | pubmed-author:HoAnthony KAK | lld:pubmed |
| pubmed-article:15358679 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15358679 | pubmed:volume | 145 | lld:pubmed |
| pubmed-article:15358679 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15358679 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15358679 | pubmed:pagination | 5723-33 | lld:pubmed |
| pubmed-article:15358679 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:15358679 | pubmed:meshHeading | pubmed-meshheading:15358679... | lld:pubmed |
| pubmed-article:15358679 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15358679 | pubmed:articleTitle | Norepinephrine induction of mitogen-activated protein kinase phosphatase-1 expression in rat pinealocytes: distinct roles of alpha- and beta-adrenergic receptors. | lld:pubmed |
| pubmed-article:15358679 | pubmed:affiliation | Department of Physiology, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada T6G 2H7. | lld:pubmed |
| pubmed-article:15358679 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15358679 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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