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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1992-6-23
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pubmed:abstractText |
We describe a 58-year-old man with tularemia and expanding gamma delta T cells in his peripheral blood lymphocytes (PBL) (32.7% of total PBL). In the present work, we analyzed the T-cell receptor V gamma/V delta repertoire of these cells by making use of the polymerase chain reaction and flow cytometry and found that they were mostly CD4- CD8- CD3+ V gamma 9/V delta 2+. The sequence analysis of 16 cDNA clones encoding the V gamma 9-J region revealed that the V gamma 9-Jp combination was strikingly overrepresented but that the junctional (N) region was heterogeneous. This suggested that the gamma delta T cells in PBL from a patient with tularemia were polyclonally expanded.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-1688874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-1694206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-1703211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-1706480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-1825059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-1848685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-2110187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-2141626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-2185544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-2377230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-2439105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-2450164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-2456364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-2471938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-2473405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-2474831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-2516219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-2521300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-2522086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-2524009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-2524098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-2524273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-2524876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-2526925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-2653369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-2820713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-2879283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-2938743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-2975601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-3055853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-3102966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-3126396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-3126397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-3131422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-3396540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-3487737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-3755221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534075-6546423
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2554-8
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1534075-Antigens, CD4,
pubmed-meshheading:1534075-Antigens, CD8,
pubmed-meshheading:1534075-Base Sequence,
pubmed-meshheading:1534075-Humans,
pubmed-meshheading:1534075-Male,
pubmed-meshheading:1534075-Middle Aged,
pubmed-meshheading:1534075-Molecular Sequence Data,
pubmed-meshheading:1534075-Polymerase Chain Reaction,
pubmed-meshheading:1534075-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:1534075-T-Lymphocytes,
pubmed-meshheading:1534075-Tularemia
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pubmed:year |
1992
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pubmed:articleTitle |
Predominant expansion of V gamma 9/V delta 2 T cells in a tularemia patient.
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pubmed:affiliation |
Second Department of Internal Medicine, School of Medicine, Chiba University, Japan.
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
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