Source:http://linkedlifedata.com/resource/pubmed/id/15337984
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2004-8-31
|
| pubmed:abstractText |
Topical treatment of cutaneous lupus erythematosus usually includes potent glucocorticosteroids. However, prolonged use causes adverse side effects including skin atrophy as the foremost concern. In contrast to glucocorticosteroids, the anti-inflammatory and immunosuppressive macrolactam pimecrolimus has no atrophogenic potential. Affected areas of 11 patients with different forms of lupus erythematosus were treated with pimecrolimus 1% cream under semiocclusive conditions twice daily for 3 weeks. Skin involvement before and after therapy was assessed by means of a clinical score. In all patients, significant regression of skin lesions was observed after therapy (P <.001). This was an open and uncontrolled study on a limited number of cases. We suggest that pimecrolimus 1% cream could be an efficacious and safe treatment option for cutaneous lupus erythematosus.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
1097-6787
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
51
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
407-10
|
| pubmed:meshHeading |
pubmed-meshheading:15337984-Administration, Cutaneous,
pubmed-meshheading:15337984-Adolescent,
pubmed-meshheading:15337984-Adult,
pubmed-meshheading:15337984-Aged,
pubmed-meshheading:15337984-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:15337984-Child,
pubmed-meshheading:15337984-Facial Dermatoses,
pubmed-meshheading:15337984-Female,
pubmed-meshheading:15337984-Humans,
pubmed-meshheading:15337984-Immunosuppressive Agents,
pubmed-meshheading:15337984-Lupus Erythematosus, Cutaneous,
pubmed-meshheading:15337984-Lupus Erythematosus, Discoid,
pubmed-meshheading:15337984-Lupus Erythematosus, Systemic,
pubmed-meshheading:15337984-Male,
pubmed-meshheading:15337984-Middle Aged,
pubmed-meshheading:15337984-Patient Acceptance of Health Care,
pubmed-meshheading:15337984-Tacrolimus,
pubmed-meshheading:15337984-Treatment Outcome
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Pimecrolimus 1% cream for cutaneous lupus erythematosus.
|
| pubmed:affiliation |
Department of Dermatology and Allergology, Ruhr-University Bochum, Germany.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial
|