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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2004-8-24
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pubmed:abstractText |
Juvenile open-angle glaucoma (JOAG) differs from primary open-angle glaucoma in that it is usually a more severe phenotype and has an earlier age of onset. Optineurin was recently associated with a variant of POAG that is characterized by intraocular pressure within normal limits: normal-tension glaucoma. The present study tested whether OPTN sequence changes play a role in early-onset glaucoma characterized by elevated intraocular pressure.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0146-0404
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pubmed:author |
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pubmed:copyrightInfo |
Copyright Association for Research in Vision and Ophthalmology
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pubmed:issnType |
Print
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3122-30
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15326130-Adolescent,
pubmed-meshheading:15326130-Adult,
pubmed-meshheading:15326130-Arginine,
pubmed-meshheading:15326130-Base Sequence,
pubmed-meshheading:15326130-Child,
pubmed-meshheading:15326130-Computational Biology,
pubmed-meshheading:15326130-DNA,
pubmed-meshheading:15326130-Female,
pubmed-meshheading:15326130-Genome, Human,
pubmed-meshheading:15326130-Genotype,
pubmed-meshheading:15326130-Glaucoma, Open-Angle,
pubmed-meshheading:15326130-Histidine,
pubmed-meshheading:15326130-Humans,
pubmed-meshheading:15326130-Intraocular Pressure,
pubmed-meshheading:15326130-Leucine,
pubmed-meshheading:15326130-Lysine,
pubmed-meshheading:15326130-Male,
pubmed-meshheading:15326130-Methionine,
pubmed-meshheading:15326130-Molecular Sequence Data,
pubmed-meshheading:15326130-Mutation,
pubmed-meshheading:15326130-Pedigree,
pubmed-meshheading:15326130-Phenotype,
pubmed-meshheading:15326130-Transcription, Genetic,
pubmed-meshheading:15326130-Transcription Factor TFIIIA,
pubmed-meshheading:15326130-Visual Fields
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pubmed:year |
2004
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pubmed:articleTitle |
Defining the pathogenicity of optineurin in juvenile open-angle glaucoma.
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pubmed:affiliation |
Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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