Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2004-7-27
pubmed:abstractText
The mi (microphthalmia) locus of mice encodes a transcription factor, MITF. B6-tg/tg mice that do not express any MITF have white coats and small eyes. Moreover, the number of mast cells decreased to one-third that of normal control (+/+) mice in the skin of B6-tg/tg mice. No mast cells were detectable in the stomach, mesentery, and peritoneal cavity of B6-tg/tg mice. Cultured mast cells derived from B6-tg/tg mice do not express a mast cell adhesion molecule, spermatogenic immunoglobulin superfamily (SgIGSF). To obtain in vivo evidence for the correlation of nonexpression of SgIGSF with decrease in mast cell number, we used another MITF mutant, B6-mi(vit)/mi(vit) mice that have a mild phenotype, ie, black coat with white patches and eyes of normal size. B6-mi(vit)/mi(vit) mice had a normal number of mast cells in the skin, stomach, and mesentery, but the number of peritoneal mast cells decreased to one-sixth that of +/+ mice. Cultured mast cells and peritoneal mast cells of B6-mi(vit)/mi(vit) mice showed a reduced but apparently detectable level of SgIGSF expression, demonstrating the parallelism between mast cell number and expression level of SgIGSF. The number of peritoneal mast cells appeared to be influenced by MITF through transcription of SgIGSF.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-10068667, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-10191088, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-10361115, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-11157480, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-11264169, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-11342428, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-11553913, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-11588059, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-11741327, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-11919417, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-12217379, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-12220516, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-12225788, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-12393515, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-12456501, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-12771178, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-1454815, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-1460250, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-1698283, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-1698556, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-1698557, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-1701786, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-1939089, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-1988455, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-1995638, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-2456920, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-2457811, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-2653378, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-352443, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-367470, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-3754329, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-3955636, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-6630999, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-6772444, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-7096452, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-7683920, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-7802662, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-7874168, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-7958932, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-8238251, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-8343963, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-8622664, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-8695840, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-8839840, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-8947051, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-9376586, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-9558376, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-9731055, http://linkedlifedata.com/resource/pubmed/commentcorrection/15277223-9949161
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0002-9440
pubmed:author
pubmed:issnType
Print
pubmed:volume
165
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
491-9
pubmed:dateRevised
2011-8-23
pubmed:meshHeading
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