| pubmed-article:15273120 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15273120 | lifeskim:mentions | umls-concept:C0006837 | lld:lifeskim |
| pubmed-article:15273120 | lifeskim:mentions | umls-concept:C0012655 | lld:lifeskim |
| pubmed-article:15273120 | lifeskim:mentions | umls-concept:C0005821 | lld:lifeskim |
| pubmed-article:15273120 | lifeskim:mentions | umls-concept:C0014118 | lld:lifeskim |
| pubmed-article:15273120 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:15273120 | lifeskim:mentions | umls-concept:C0016277 | lld:lifeskim |
| pubmed-article:15273120 | lifeskim:mentions | umls-concept:C0678226 | lld:lifeskim |
| pubmed-article:15273120 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:15273120 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:15273120 | lifeskim:mentions | umls-concept:C1517004 | lld:lifeskim |
| pubmed-article:15273120 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:15273120 | pubmed:dateCreated | 2004-7-26 | lld:pubmed |
| pubmed-article:15273120 | pubmed:abstractText | Platelet microbicidal proteins (PMPs) are believed to be integral to host defense against endovascular infection. We previously demonstrated that susceptibility to thrombin-induced PMP 1 (tPMP-1) in vitro negatively influences Candida albicans virulence in the rabbit model of infective endocarditis (IE). This study evaluated the relationship between in vitro tPMP-1 susceptibility (tPMP-1s) or resistance (tPMP-1r) and efficacy of fluconazole (FLU) therapy of IE due to C. albicans. Candida IE was established in rabbits with either tPMP-1s or tPMP-1r strains. Treatment groups received FLU (100 mg/kg/day) intraperitoneally for 7 or 14 days; control animals received no therapy. At these time points, cardiac vegetations, kidneys, and spleens were quantitatively cultured to assess fungal burden. At both 7 and 14 days and in all target tissues, the extent of candidal clearance by FLU was greater in animals infected with the tPMP-1s strain than in those infected with the tPMP-1r strain. These differences were statistically significant in the spleen and kidney. Corroborating these in vivo data, FLU (a candidastatic agent), in combination with tPMP-1, exerted an enhanced fungicidal effect in vitro against tPMP-1s and tPMP-1r C. albicans, with the extent of this effect greatest against the tPMP-1s strain. Collectively, these results support the concept that tPMP-1 susceptibility contributes to the net efficacy of FLU against C. albicans IE in vivo, particularly in tissues in which platelets and tPMP-1 likely play significant roles in host defense. | lld:pubmed |
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| pubmed-article:15273120 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15273120 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15273120 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15273120 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15273120 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15273120 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:15273120 | pubmed:issn | 0066-4804 | lld:pubmed |
| pubmed-article:15273120 | pubmed:author | pubmed-author:XiongYan-Qion... | lld:pubmed |
| pubmed-article:15273120 | pubmed:author | pubmed-author:BayerArnold... | lld:pubmed |
| pubmed-article:15273120 | pubmed:author | pubmed-author:YeamanMichael... | lld:pubmed |
| pubmed-article:15273120 | pubmed:author | pubmed-author:EdwardsJohn... | lld:pubmed |
| pubmed-article:15273120 | pubmed:author | pubmed-author:GankKimberly... | lld:pubmed |
| pubmed-article:15273120 | pubmed:author | pubmed-author:ChengDarwinD | lld:pubmed |
| pubmed-article:15273120 | pubmed:author | pubmed-author:DesaiBhaveshB | lld:pubmed |
| pubmed-article:15273120 | pubmed:author | pubmed-author:KupferwasserL... | lld:pubmed |
| pubmed-article:15273120 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15273120 | pubmed:volume | 48 | lld:pubmed |
| pubmed-article:15273120 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15273120 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15273120 | pubmed:pagination | 3051-6 | lld:pubmed |
| pubmed-article:15273120 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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