Linked Life Data

15261342

Source:http://linkedlifedata.com/resource/pubmed/id/15261342

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2004-7-20
pubmed:abstractText
DNA circulates in the blood in systemic lupus erythematosus, among other conditions, and plays a role in immunopathogenesis in the form of immune complexes. As shown in experiments in mice, blood DNA levels rise following treatments to induce apoptosis and the administration of cells made apoptotic or necrotic in vitro. In mice lacking macrophage function, however, blood levels do not rise following administration of dead cells. These results indicate that circulating DNA may be a marker of cell death, although its levels likely reflect a complex process involving the interactions of macrophages with dead and dying cells.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0889-857X
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
575-87, x
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
DNA as a marker of cell death in systemic lupus erythematosus.
pubmed:affiliation
Division of Rheumatology and Immunology, Duke University Medical Center, Medical Research Service, Durham, NC, USA. piset001@mc.duke.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Review