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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2004-7-8
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pubmed:databankReference |
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pubmed:abstractText |
Here we show that XsalF, a frog homolog of the Drosophila homeotic selector spalt, plays an essential role for the forebrain/midbrain determination in Xenopus. XsalF overexpression expands the domain of forebrain/midbrain genes and suppresses midbrain/hindbrain boundary (MHB) markers and anterior hindbrain genes. Loss-of-function studies show that XsalF is essential for the expression of the forebrain/midbrain genes and for the repression of the caudal genes. Interestingly, XsalF functions by antagonizing canonical Wnt signaling, which promotes caudalization of neural tissues. XsalF is required for anterior-specific expressions of GSK3beta and Tcf3, genes encoding antagonistic effectors of Wnt signaling. Loss-of-function phenotypes of GSK3beta and Tcf3 mimic those of XsalF while injections of GSK3beta and Tcf3 rescue loss-of-function phenotypes of XsalF. These findings suggest that the forebrain/midbrain-specific gene XsalF negatively controls cellular responsiveness to posteriorizing Wnt signals by regulating region-specific GSK3beta and Tcf3 expression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glycogen Synthase Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/HMGB Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/TCF Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor 7-Like 1...,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Xenopus Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/glycogen synthase kinase 3 beta,
http://linkedlifedata.com/resource/pubmed/chemical/sal protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1534-5807
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
95-106
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:15239957-Animals,
pubmed-meshheading:15239957-Brain,
pubmed-meshheading:15239957-Cell Lineage,
pubmed-meshheading:15239957-DNA, Complementary,
pubmed-meshheading:15239957-Drosophila Proteins,
pubmed-meshheading:15239957-Ectoderm,
pubmed-meshheading:15239957-Embryo, Nonmammalian,
pubmed-meshheading:15239957-Gene Expression Regulation, Developmental,
pubmed-meshheading:15239957-Glycogen Synthase Kinase 3,
pubmed-meshheading:15239957-HMGB Proteins,
pubmed-meshheading:15239957-Homeodomain Proteins,
pubmed-meshheading:15239957-Mesencephalon,
pubmed-meshheading:15239957-Molecular Sequence Data,
pubmed-meshheading:15239957-Mutation,
pubmed-meshheading:15239957-Phenotype,
pubmed-meshheading:15239957-Prosencephalon,
pubmed-meshheading:15239957-Proto-Oncogene Proteins,
pubmed-meshheading:15239957-RNA, Messenger,
pubmed-meshheading:15239957-Sequence Homology, Amino Acid,
pubmed-meshheading:15239957-Sequence Homology, Nucleic Acid,
pubmed-meshheading:15239957-Signal Transduction,
pubmed-meshheading:15239957-TCF Transcription Factors,
pubmed-meshheading:15239957-Transcription Factor 7-Like 1 Protein,
pubmed-meshheading:15239957-Transcription Factors,
pubmed-meshheading:15239957-Wnt Proteins,
pubmed-meshheading:15239957-Xenopus Proteins,
pubmed-meshheading:15239957-Xenopus laevis,
pubmed-meshheading:15239957-Zinc Fingers
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pubmed:year |
2004
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pubmed:articleTitle |
Xenopus XsalF: anterior neuroectodermal specification by attenuating cellular responsiveness to Wnt signaling.
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pubmed:affiliation |
Organogenesis and Neurogenesis Group, Center for Developmental Biology, RIKEN, Kobe 650-0047, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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