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rdf:type |
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lifeskim:mentions |
umls-concept:C0009331,
umls-concept:C0017262,
umls-concept:C0053932,
umls-concept:C0081487,
umls-concept:C0102137,
umls-concept:C0185117,
umls-concept:C0225369,
umls-concept:C0991566,
umls-concept:C1707903,
umls-concept:C2349975,
umls-concept:C2911684
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pubmed:issue |
7
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pubmed:dateCreated |
2004-6-28
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pubmed:abstractText |
For autologous chondrocyte transplantation (ACT) chondrocytes are expanded in vitro. During expansion these cells may dedifferentiate. This change in phenotype is characterized by a raised expression of type I collagen and a decrease in type II collagen expression. Since high expression of type II collagen is of central importance for the properties of hyaline cartilage, we investigated if the growth factor bone morphogenetic protein-2 (BMP-2) may modulate the chondrogenic phenotype in monolayer cell cultures and in three-dimensional culture systems.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aggrecans,
http://linkedlifedata.com/resource/pubmed/chemical/Alginates,
http://linkedlifedata.com/resource/pubmed/chemical/BMP2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein 2,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Matrix Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Proteoglycans,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/recombinant human bone...
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1063-4584
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2004 OsteoArthritis Research Society International
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
559-67
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15219571-Adult,
pubmed-meshheading:15219571-Aged,
pubmed-meshheading:15219571-Aggrecans,
pubmed-meshheading:15219571-Alginates,
pubmed-meshheading:15219571-Bone Morphogenetic Protein 2,
pubmed-meshheading:15219571-Bone Morphogenetic Proteins,
pubmed-meshheading:15219571-Cartilage, Articular,
pubmed-meshheading:15219571-Cells, Cultured,
pubmed-meshheading:15219571-Chondrocytes,
pubmed-meshheading:15219571-Collagen Type II,
pubmed-meshheading:15219571-Cytokines,
pubmed-meshheading:15219571-Drug Compounding,
pubmed-meshheading:15219571-Extracellular Matrix Proteins,
pubmed-meshheading:15219571-Female,
pubmed-meshheading:15219571-Gene Expression,
pubmed-meshheading:15219571-Humans,
pubmed-meshheading:15219571-Interleukin-1,
pubmed-meshheading:15219571-Knee Joint,
pubmed-meshheading:15219571-Lectins, C-Type,
pubmed-meshheading:15219571-Male,
pubmed-meshheading:15219571-Middle Aged,
pubmed-meshheading:15219571-Phenotype,
pubmed-meshheading:15219571-Proteoglycans,
pubmed-meshheading:15219571-Recombinant Proteins,
pubmed-meshheading:15219571-Tissue Engineering,
pubmed-meshheading:15219571-Transforming Growth Factor beta
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pubmed:year |
2004
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pubmed:articleTitle |
Bone morphogenetic protein (BMP)-2 enhances the expression of type II collagen and aggrecan in chondrocytes embedded in alginate beads.
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pubmed:affiliation |
TETEC AG, Aspenhaustrasse 25, 72770 Reutlingen, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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