Linked Life Data

1519771

Source:http://linkedlifedata.com/resource/pubmed/id/1519771

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1992-10-8
pubmed:abstractText
In 1974 Miklos reviewed evidence suggesting an association between sex chromosome pairing failure and spermatogenic arrest. He proposed that distributed over all the chromosomes there are 'meiotic pairing sites' which must be 'saturated' by homologous pairing during pachytene. In unpaired regions these sites are 'activated', and set in motion a process which leads ultimately to the death of the cell. In the present 'extended abstract' we summarize studies we have carried out on XSxraO male mice, that substantiate the main tenets of Miklos' model. Miklos' model is then used as a basis for explaining data we have collected on a large series of XYY male mice.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0303-4569
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
17-20
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:articleTitle
The role of unpaired sex chromosomes in spermatogenic failure.
pubmed:affiliation
MRC Mammalian Development Unit, Wolfson House, London, UK.
pubmed:publicationType
Journal Article, Review