Linked Life Data

15163177

Source:http://linkedlifedata.com/resource/pubmed/id/15163177

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:15163177rdf:typepubmed:Citationlld:pubmed
pubmed-article:15163177lifeskim:mentionsumls-concept:C0521329lld:lifeskim
pubmed-article:15163177lifeskim:mentionsumls-concept:C0064239lld:lifeskim
pubmed-article:15163177lifeskim:mentionsumls-concept:C0031437lld:lifeskim
pubmed-article:15163177lifeskim:mentionsumls-concept:C0023688lld:lifeskim
pubmed-article:15163177lifeskim:mentionsumls-concept:C0599894lld:lifeskim
pubmed-article:15163177lifeskim:mentionsumls-concept:C1705241lld:lifeskim
pubmed-article:15163177lifeskim:mentionsumls-concept:C0439097lld:lifeskim
pubmed-article:15163177lifeskim:mentionsumls-concept:C1547348lld:lifeskim
pubmed-article:15163177lifeskim:mentionsumls-concept:C1453197lld:lifeskim
pubmed-article:15163177pubmed:issue12lld:pubmed
pubmed-article:15163177pubmed:dateCreated2004-5-27lld:pubmed
pubmed-article:15163177pubmed:abstractTextIn view of recent pharmacological studies suggesting the existence of delta-kappa opioid receptor heterodimers/oligomers in the spinal cord, we have synthesized and evaluated (intrathecally in mice) a series of bivalent ligands (KDN series) containing kappa and delta antagonist pharmacophores. Pharmacological and binding data have provided evidence for the bridging of spinal delta-kappa receptor heterodimers by KDN-21 and for their identification as delta(1) and kappa(2). The selectivity profile of KDN-21 and the apparent absence of coupled delta(1)-kappa(2) phenotypes in the brain suggest a new approach for targeting receptors.lld:pubmed
pubmed-article:15163177pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15163177pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15163177pubmed:languageenglld:pubmed
pubmed-article:15163177pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15163177pubmed:citationSubsetIMlld:pubmed
pubmed-article:15163177pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15163177pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15163177pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15163177pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15163177pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15163177pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15163177pubmed:statusMEDLINElld:pubmed
pubmed-article:15163177pubmed:monthJunlld:pubmed
pubmed-article:15163177pubmed:issn0022-2623lld:pubmed
pubmed-article:15163177pubmed:authorpubmed-author:SharmaShiv...lld:pubmed
pubmed-article:15163177pubmed:authorpubmed-author:PortoghesePhi...lld:pubmed
pubmed-article:15163177pubmed:authorpubmed-author:BhushanRashmi...lld:pubmed
pubmed-article:15163177pubmed:authorpubmed-author:XieZhihuaZlld:pubmed
pubmed-article:15163177pubmed:authorpubmed-author:DanielsDavid...lld:pubmed
pubmed-article:15163177pubmed:issnTypePrintlld:pubmed
pubmed-article:15163177pubmed:day3lld:pubmed
pubmed-article:15163177pubmed:volume47lld:pubmed
pubmed-article:15163177pubmed:ownerNLMlld:pubmed
pubmed-article:15163177pubmed:authorsCompleteYlld:pubmed
pubmed-article:15163177pubmed:pagination2969-72lld:pubmed
pubmed-article:15163177pubmed:dateRevised2007-11-14lld:pubmed
pubmed-article:15163177pubmed:meshHeadingpubmed-meshheading:15163177...lld:pubmed
pubmed-article:15163177pubmed:meshHeadingpubmed-meshheading:15163177...lld:pubmed
pubmed-article:15163177pubmed:meshHeadingpubmed-meshheading:15163177...lld:pubmed
pubmed-article:15163177pubmed:meshHeadingpubmed-meshheading:15163177...lld:pubmed
pubmed-article:15163177pubmed:meshHeadingpubmed-meshheading:15163177...lld:pubmed
pubmed-article:15163177pubmed:meshHeadingpubmed-meshheading:15163177...lld:pubmed
pubmed-article:15163177pubmed:meshHeadingpubmed-meshheading:15163177...lld:pubmed
pubmed-article:15163177pubmed:meshHeadingpubmed-meshheading:15163177...lld:pubmed
pubmed-article:15163177pubmed:meshHeadingpubmed-meshheading:15163177...lld:pubmed
pubmed-article:15163177pubmed:meshHeadingpubmed-meshheading:15163177...lld:pubmed
pubmed-article:15163177pubmed:meshHeadingpubmed-meshheading:15163177...lld:pubmed
pubmed-article:15163177pubmed:year2004lld:pubmed
pubmed-article:15163177pubmed:articleTitleA bivalent ligand (KDN-21) reveals spinal delta and kappa opioid receptors are organized as heterodimers that give rise to delta(1) and kappa(2) phenotypes. Selective targeting of delta-kappa heterodimers.lld:pubmed
pubmed-article:15163177pubmed:affiliationDepartment of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.lld:pubmed
pubmed-article:15163177pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15163177pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
http://linkedlifedata.com/r...http://linkedlifedata.com/r...pubmed-article:15163177lld:chembl
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15163177lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15163177lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15163177lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15163177lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15163177lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15163177lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15163177lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15163177lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15163177lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15163177lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15163177lld:pubmed