Linked Life Data

1513434

Source:http://linkedlifedata.com/resource/pubmed/id/1513434

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1992-10-1
pubmed:abstractText
The influence of the inhalational anesthetics halothane, enflurane, and isoflurane on motor evoked potentials was studied in a total of 10 rabbits. Motor evoked potentials were recorded from the extremity muscles as well as from the epidural space of the spinal cord and cauda equina in response to electrical stimulation of the motor cortex at baseline conditions and equianesthetic concentrations (0.25 to 1.5 minimal alveolar concentration). Our results show a dose-dependent suppression of the electromyographic responses, which was similar with all anesthetics. Beyond 0.5 minimal alveolar concentration of any of the agents, electromyographic responses were absent. In contrast, spinal evoked responses representing neural activity were only slightly affected by the anesthetics. We hypothesize that the descending impulse elicited by the electrical stimulation of the motor cortex is mainly inhibited at the level of the spinal interneuronal or motoneuronal systems, because 1) electromyographic responses evoked by the stimulation of the cervical and lumbar nerve roots were only minimally affected by 1.5 minimal alveolar concentration halothane; and 2) spinal evoked responses were stable several minutes after cardiac arrest, indicating a subcortical action site of the electrical impulse. In conclusion, intraoperative monitoring of descending pathways by means of motor evoked potentials during anesthesia with the inhalational agents halothane, enflurane and isoflurane is only feasible when neural activity is evaluated.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0148-396X
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
298-305
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Influence of halothane, enflurane, and isoflurane on motor evoked potentials.
pubmed:affiliation
Department of Neurosurgery, Medical School, University of Tübingen, Germany.
pubmed:publicationType
Journal Article, Comparative Study