| pubmed-article:15115403 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15115403 | lifeskim:mentions | umls-concept:C0005496 | lld:lifeskim |
| pubmed-article:15115403 | lifeskim:mentions | umls-concept:C0596902 | lld:lifeskim |
| pubmed-article:15115403 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:15115403 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:15115403 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:15115403 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:15115403 | lifeskim:mentions | umls-concept:C0205464 | lld:lifeskim |
| pubmed-article:15115403 | lifeskim:mentions | umls-concept:C0243072 | lld:lifeskim |
| pubmed-article:15115403 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:15115403 | pubmed:dateCreated | 2004-4-29 | lld:pubmed |
| pubmed-article:15115403 | pubmed:abstractText | In our efforts toward developing a nonselective ligand that would block the effects of stimulants such as methamphetamine at dopamine (DA), serotonin (5-HT), and norepinephrine (NE) transporters, we synthesized a series of 3-(3,4-dichlorophenyl)-1-indanamine derivatives. Two of the examined higher affinity compounds had a phenolic hydroxyl group enabling preparation of a medium to long chain carboxylic acid ester that might eventually be useful for a long-acting depot formulation. The in vitro data indicated that (-)-(1R,3S)-trans-3-(3,4-dichlorophenyl)-6-hydroxy-N-methyl-1-indanamine ((-)-(1R,3S)-11) displays high-affinity binding and potent inhibition of uptake at all three biogenic amine transporters. In vivo microdialysis experiments demonstrated that intravenous administration of (-)-(1R,3S)-11 to rats elevated extracellular DA and 5-HT in the nucleus accumbens in a dose-dependent manner. Pretreating rats with 0.5 mg/kg (-)-(1R,3S)-11 elevated extracellular DA and 5-HT by approximately 150% and reduced methamphetamine-induced neurotransmitter release by about 50%. Ex vivo autoradiography, however, demonstrated that iv administration of (-)-(1R,3S)-11 produced a dose-dependent, persistent occupation of 5-HT transporter binding sites but not DA transporter sites. | lld:pubmed |
| pubmed-article:15115403 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15115403 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15115403 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15115403 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15115403 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15115403 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15115403 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15115403 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15115403 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15115403 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15115403 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15115403 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15115403 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15115403 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15115403 | pubmed:month | May | lld:pubmed |
| pubmed-article:15115403 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:15115403 | pubmed:author | pubmed-author:FRYDD | lld:pubmed |
| pubmed-article:15115403 | pubmed:author | pubmed-author:TianXinrongX | lld:pubmed |
| pubmed-article:15115403 | pubmed:author | pubmed-author:JacobsonArthu... | lld:pubmed |
| pubmed-article:15115403 | pubmed:author | pubmed-author:RiceKenner... | lld:pubmed |
| pubmed-article:15115403 | pubmed:author | pubmed-author:DerschChristi... | lld:pubmed |
| pubmed-article:15115403 | pubmed:author | pubmed-author:RothmanRichar... | lld:pubmed |
| pubmed-article:15115403 | pubmed:author | pubmed-author:BaumannMichae... | lld:pubmed |
| pubmed-article:15115403 | pubmed:author | pubmed-author:Flippen-Ander... | lld:pubmed |
| pubmed-article:15115403 | pubmed:author | pubmed-author:FolkJohn EJE | lld:pubmed |
| pubmed-article:15115403 | pubmed:author | pubmed-author:KimIn JongIJ | lld:pubmed |
| pubmed-article:15115403 | pubmed:author | pubmed-author:ParrishDamonD | lld:pubmed |
| pubmed-article:15115403 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15115403 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:15115403 | pubmed:volume | 47 | lld:pubmed |
| pubmed-article:15115403 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15115403 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15115403 | pubmed:pagination | 2624-34 | lld:pubmed |
| pubmed-article:15115403 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15115403 | pubmed:meshHeading | pubmed-meshheading:15115403... | lld:pubmed |
| pubmed-article:15115403 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15115403 | pubmed:articleTitle | Synthesis and pharmacological evaluation of 3-(3,4-dichlorophenyl)-1-indanamine derivatives as nonselective ligands for biogenic amine transporters. | lld:pubmed |
| pubmed-article:15115403 | pubmed:affiliation | Laboratory of Medicinal Chemistry, Building 8, Room B1-23, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, 20892-0815, USA. | lld:pubmed |
| pubmed-article:15115403 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15115403 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:15115403 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15115403 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:15115403 | lld:chembl |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15115403 | lld:pubmed |
