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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2004-4-27
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pubmed:abstractText |
Thio-heterocyclic fused naphthalimides with aminoalkyl side chains were designed, synthesized and evaluated. These compounds have long wavelength absorptions and binding affinities to Calf thymus DNA. They could photodamage supercoiled pBR322 DNA from form I (closed) to II (nicked) at a concentration as low as 0.5 microM and to form III (linear) at a concentration of 50 microM. A possible mechanism of superoxide anion was provided.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2665-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15109674-Amines,
pubmed-meshheading:15109674-Animals,
pubmed-meshheading:15109674-DNA,
pubmed-meshheading:15109674-DNA Damage,
pubmed-meshheading:15109674-Drug Design,
pubmed-meshheading:15109674-Heterocyclic Compounds with 4 or More Rings,
pubmed-meshheading:15109674-Imides,
pubmed-meshheading:15109674-Light,
pubmed-meshheading:15109674-Photolysis,
pubmed-meshheading:15109674-Plasmids,
pubmed-meshheading:15109674-Radiation-Sensitizing Agents,
pubmed-meshheading:15109674-Structure-Activity Relationship,
pubmed-meshheading:15109674-Sulfides
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pubmed:year |
2004
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pubmed:articleTitle |
Highly-efficient DNA photocleavers with long wavelength absorptions: thio-heterocyclic fused naphthalimides containing aminoalkyl side chains.
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pubmed:affiliation |
State Key Laboratory of Fine Chemicals, Dalian University of Technology, PO Box 40, 158 Zhongshan Road, Dalian 116012, China. xhqian@dlut.edu.cn
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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