1510416

Source:http://linkedlifedata.com/resource/pubmed/id/1510416

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0026140, umls-concept:C0053882, umls-concept:C0086418, umls-concept:C0221102
pubmed:issue	5
pubmed:dateCreated	1992-9-22
pubmed:abstractText	The excretion of cefprozil into breast milk in nine healthy, lactating female subjects was investigated. Each subject received a single 1,000-mg oral dose of cefprozil consisting of cis and trans isomers in an approximately 90:10 ratio. Serial blood, urine, and breast milk samples were collected and analyzed for the concentrations of the cis and trans isomers by a specific high-pressure liquid chromatography-UV assay. The mean pharmacokinetic parameters for both isomers were essentially the same. The mean peak concentrations in plasma for the cis isomer were 14.8 micrograms/ml, and the area under the concentration curve was 54.8 micrograms.h/ml. The mean values of elimination half-life, renal clearance, and urinary excretion for the cis isomer were 1.69 h, 164 ml/min, and 60%, respectively. The mean concentrations in milk of the cis isomer over a 24-h period ranged from 0.25 to 3.36 micrograms/ml, with the maximum concentration appearing at 6 h after dosing. The average maximum concentration in milk of the trans isomer was less than 0.26 micrograms/ml. The concentrations of the trans isomer in plasma and in breast milk were about 1/10 of those for the cis isomer. Less than 0.3% of the dose was excreted in breast milk for both isomers of cefprozil. Even if one assumes that the concentration of cefprozil in milk remains constant at 3.36 micrograms/ml (the highest concentration of cefprozil observed in breast milk), an infant ingesting an average of 800 ml of milk per day will be exposed to a maximum amount of about 3 mg of cefprozil per day. This value represents about 0.3% of the maternal dose. Low excretion of cefprozil in breast milk and the excellent safety profile of cefprozil suggest that this cephalosporin may be administered to nursing mothers when indicated.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/1510416-1924169, http://linkedlifedata.com/resource/pubmed/commentcorrection/1510416-2037710, http://linkedlifedata.com/resource/pubmed/commentcorrection/1510416-2037711, http://linkedlifedata.com/resource/pubmed/commentcorrection/1510416-2327766, http://linkedlifedata.com/resource/pubmed/commentcorrection/1510416-2393281, http://linkedlifedata.com/resource/pubmed/commentcorrection/1510416-2393283, http://linkedlifedata.com/resource/pubmed/commentcorrection/1510416-2515321, http://linkedlifedata.com/resource/pubmed/commentcorrection/1510416-3105449, http://linkedlifedata.com/resource/pubmed/commentcorrection/1510416-3169119, http://linkedlifedata.com/resource/pubmed/commentcorrection/1510416-3452637, http://linkedlifedata.com/resource/pubmed/commentcorrection/1510416-3495236, http://linkedlifedata.com/resource/pubmed/commentcorrection/1510416-3496846, http://linkedlifedata.com/resource/pubmed/commentcorrection/1510416-3606067, http://linkedlifedata.com/resource/pubmed/commentcorrection/1510416-3890712, http://linkedlifedata.com/resource/pubmed/commentcorrection/1510416-6311089, http://linkedlifedata.com/resource/pubmed/commentcorrection/1510416-6743732, http://linkedlifedata.com/resource/pubmed/commentcorrection/1510416-7246123, http://linkedlifedata.com/resource/pubmed/commentcorrection/1510416-7252794, http://linkedlifedata.com/resource/pubmed/commentcorrection/1510416-7334140, http://linkedlifedata.com/resource/pubmed/commentcorrection/1510416-758399
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0315061
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Cephalosporins, http://linkedlifedata.com/resource/pubmed/chemical/cefprozil
pubmed:status	MEDLINE
pubmed:month	May
pubmed:issn	0066-4804
pubmed:author	pubmed-author:BarbhaiyaR HRH, pubmed-author:CampbellD ADA, pubmed-author:JaganathanVV, pubmed-author:PittmanK AKA, pubmed-author:ShahV RVR, pubmed-author:ShyuW CWC, pubmed-author:VenitzJJ, pubmed-author:WilberR BRB
pubmed:issnType	Print
pubmed:volume	36
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	938-41
pubmed:dateRevised	2010-9-7
pubmed:meshHeading	pubmed-meshheading:1510416-Administration, Oral, pubmed-meshheading:1510416-Cephalosporins, pubmed-meshheading:1510416-Female, pubmed-meshheading:1510416-Humans, pubmed-meshheading:1510416-Milk, Human
pubmed:year	1992
pubmed:articleTitle	Excretion of cefprozil into human breast milk.
pubmed:affiliation	Department of Metabolism and Pharmacokinetics, Bristol-Myers Squibb Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Syracuse, New York 13221-4755.
pubmed:publicationType	Journal Article