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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2004-7-22
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pubmed:abstractText |
Although previous data suggested that only doses of 4 g/day or higher of n-3 polyunsaturated fatty acids (PUFA) have had a beneficial effect in the prevention of atherosclerosis and cardiovascular diseases, the GISSI-Prevenzione Study in a 3-year trial showed that 1 g/day reduced total and cardiovascular mortality in over 11,000 post-infarction patients. The aim of this study was to investigate the time course and the extent of incorporation of n-3 fatty acids in plasma and blood cells after 1 g/day of n-3 PUFA, the dose effective in the GISSI-Prevenzione in comparison with higher doses.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0031-6970
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
183-90
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15069592-Administration, Oral,
pubmed-meshheading:15069592-Adult,
pubmed-meshheading:15069592-Biotransformation,
pubmed-meshheading:15069592-Blood Platelets,
pubmed-meshheading:15069592-Capsules,
pubmed-meshheading:15069592-Cardiovascular Diseases,
pubmed-meshheading:15069592-Clinical Trials as Topic,
pubmed-meshheading:15069592-Docosahexaenoic Acids,
pubmed-meshheading:15069592-Dose-Response Relationship, Drug,
pubmed-meshheading:15069592-Drug Administration Schedule,
pubmed-meshheading:15069592-Eicosapentaenoic Acid,
pubmed-meshheading:15069592-Fatty Acids, Omega-3,
pubmed-meshheading:15069592-Fatty Acids, Omega-6,
pubmed-meshheading:15069592-Humans,
pubmed-meshheading:15069592-Male,
pubmed-meshheading:15069592-Monocytes,
pubmed-meshheading:15069592-Phospholipids,
pubmed-meshheading:15069592-Time Factors,
pubmed-meshheading:15069592-Tocopherols,
pubmed-meshheading:15069592-Triglycerides
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pubmed:year |
2004
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pubmed:articleTitle |
Early modifications of fatty acid composition in plasma phospholipids, platelets and mononucleates of healthy volunteers after low doses of n-3 polyunsaturated fatty acids.
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pubmed:affiliation |
Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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