Linked Life Data

15057110

Source:http://linkedlifedata.com/resource/pubmed/id/15057110

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
420
pubmed:dateCreated
2004-4-1
pubmed:abstractText
Evidence suggests neovascularization is involved in the etiology of spontaneous Achilles tendon rupture. Therefore we investigated expression of the receptors of one of the most important angiogenic factors, the vascular endothelial growth factor in normal and pathologic human Achilles tendons by immunohistochemical and molecular biology methods. Light microscopy showed degenerative changes in all spontaneously ruptured tendons with a higher vascular density compared with controls of healthy tendons from a cadaver. The vascular endothelial growth factor receptors-1 and 2 could be immunostained in endothelial cells of ruptured and fetal tendons, but not in normal tendons. Reverse transcription-polymerase chain reaction showed messenger ribonucleic acid of both receptors are expressed in ruptured and fetal tendons but not in normal tendons. These results prove the reexpression of the major receptors for the angiogenic peptide vascular endothelial growth factor, the vascular endothelial growth factor receptor-1, and the vascular endothelial growth factor receptor-2 in ruptured and fetal tendons and support our theory that high vascular density is associated with the pathogenesis of tendon degenerations. Inhibiting angiogenesis could be a new approach in the therapy of degenerative Achilles tendon disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0009-921X
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
286-91
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Expression of VEGFR-1 and VEGFR-2 in degenerative Achilles tendons.
pubmed:affiliation
Department of Orthopaedic Surgery, Christian-Albrechts-University of Kiel, Michaelisstrasse 1, D-24105 Kiel, Germany. wolfpetersen@hotmail.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't