Source:http://linkedlifedata.com/resource/pubmed/id/15041728
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2004-3-25
|
| pubmed:abstractText |
The biological properties of CCN proteins include stimulation of cell proliferation, migration, and adhesion, as well as angiogenesis and tumorigenesis. We quantified CYR61, CTGF, WISP-1, and NOV mRNA expression levels in samples from sixty-six primary gliomas and five normal brain samples using quantitative real-time PCR assay. Statistical analysis was performed to explore the links between expression of the CCN genes and clinical and pathological parameters. Overexpression of CYR61, CTGF, WISP-1, and NOV occurred in 48% (32 of 66), 58% (38 of 66), 36% (24 of 66), and 15% (10 of 66) of primary gliomas, respectively. Interestingly, significant associations were found between CYR61 expression versus tumor grade, pathology, gender, and age at diagnosis. Also, a significant correlation existed between CTGF mRNA levels versus tumor grade, gender, and pathology. In contrast to CYR61 and CTGF, no significant association was found between expression of either WISP-1 or NOV versus any of the pathological features. Furthermore, Cox regression analysis showed that CYR61 and CTGF expression had a significant correlation with patient survival. These results suggest that CYR61 and CTGF may play a role in the progression of gliomas; their levels at diagnosis may have prognostic significance; and these proteins might serve as valuable targets for therapeutic intervention.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CTGF protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CYR61 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Connective Tissue Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Cysteine-Rich Protein 61,
http://linkedlifedata.com/resource/pubmed/chemical/Immediate-Early Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/NOV protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nephroblastoma Overexpressed Protein
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
1078-0432
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
10
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2072-81
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:15041728-Adult,
pubmed-meshheading:15041728-Brain Neoplasms,
pubmed-meshheading:15041728-Connective Tissue Growth Factor,
pubmed-meshheading:15041728-Cysteine-Rich Protein 61,
pubmed-meshheading:15041728-Disease Progression,
pubmed-meshheading:15041728-Female,
pubmed-meshheading:15041728-Glioma,
pubmed-meshheading:15041728-Humans,
pubmed-meshheading:15041728-Immediate-Early Proteins,
pubmed-meshheading:15041728-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:15041728-Male,
pubmed-meshheading:15041728-Middle Aged,
pubmed-meshheading:15041728-Nephroblastoma Overexpressed Protein,
pubmed-meshheading:15041728-Prognosis,
pubmed-meshheading:15041728-Retrospective Studies,
pubmed-meshheading:15041728-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15041728-Survival Analysis,
pubmed-meshheading:15041728-Time Factors
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Levels of expression of CYR61 and CTGF are prognostic for tumor progression and survival of individuals with gliomas.
|
| pubmed:affiliation |
Division of Hematology/Oncology, Cedars-Sinai Medical Center, University of California-Los Angeles (UCLA) School of Medicine, Los Angeles, California 90048, USA. xied@ucla.edu
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|