|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2004-3-18
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|
pubmed:abstractText |
A quantitative structure-activity relationship (QSAR) study was performed on a set of 49 negative allosteric modulators of AMPA receptor, acting as anticonvulsant agents, using multiple linear regression. The predictive ability of the resulting model was evaluated against a set of 12 compounds; the results showed good statistics in regression and revealed high correlation between anticonvulsant activity and some electrotopological descriptors.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0022-2623
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
25
|
|
pubmed:volume |
47
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1860-3
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|
pubmed:dateRevised |
2008-11-21
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|
pubmed:meshHeading |
pubmed-meshheading:15027880-Allosteric Regulation,
pubmed-meshheading:15027880-Anticonvulsants,
pubmed-meshheading:15027880-Benzodiazepines,
pubmed-meshheading:15027880-Excitatory Amino Acid Antagonists,
pubmed-meshheading:15027880-Isoquinolines,
pubmed-meshheading:15027880-Linear Models,
pubmed-meshheading:15027880-Models, Biological,
pubmed-meshheading:15027880-Phthalazines,
pubmed-meshheading:15027880-Quantitative Structure-Activity Relationship,
pubmed-meshheading:15027880-Receptors, AMPA
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
QSAR study of anticonvulsant negative allosteric modulators of the AMPA receptor.
|
|
pubmed:affiliation |
Dipartimento di Chimica e Tecnologia del Farmaco, Università di Perugia, Via del Liceo 1 06123 Perugia, Italy.
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|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
